Evidence map›Paper›PMID 32883229›Full record

ArticleBMC cancer2020

Cell-in-cell phenomenon associates with aggressive characteristics and cancer-related mortality in early oral tongue cancer.

Alhadi Almangush, Antti A Mäkitie, Jaana Hagström, Caj Haglund, Luiz Paulo Kowalski, Pentti Nieminen, Ricardo D Coletta, Tuula Salo, Ilmo Leivo

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

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  14. Homotypic Entosis as a Potential Novel Diagnostic Marker in Breast Cancer.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Alhadi AlmangushDepartment of Pathology, University of Helsinki, Haartmaninkatu 3 (P.O. Box 21), FIN-00014, Helsinki, Finland. alhadi.almangush@helsinki.fi.ORCID http://orcid.org/0000-0003-4106-314X
Antti A MäkitieResearch Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Jaana HagströmDepartment of Pathology, University of Helsinki, Haartmaninkatu 3 (P.O. Box 21), FIN-00014, Helsinki, Finland.
Caj HaglundResearch Programs Unit, Translational Cancer Medicine, University of Helsinki, Helsinki, Finland.
Luiz Paulo KowalskiDepartment of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, Brazil.
Pentti NieminenMedical Informatics and Data Analysis Research Group, University of Oulu, Oulu, Finland.
Ricardo D ColettaDepartment of Oral Diagnosis, School of Dentistry, University of Campinas, Piracicaba, São Paulo, Brazil.
Tuula SaloDepartment of Pathology, University of Helsinki, Haartmaninkatu 3 (P.O. Box 21), FIN-00014, Helsinki, Finland.
Ilmo LeivoInstitute of Biomedicine, Pathology, University of Turku, Turku, Finland.
University of Helsinki · FIKarolinska University Hospital · SEUniversidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BRUniversity of Oulu · FIUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCell-in-cell structures (caused by cell cannibalistic activity) have been related to prognosis of many cancers. This is the first multi-institutional study to assess the prognostic impact of cell-in-cell structures in a large cohort of early oral tongue squamous cell carcinomas (OTSCC).

methodsA total of 308 cases from five Finnish University Hospitals and from the A.C. Camargo Cancer Center, São Paulo, Brazil, were included in this study. Cell-in-cell structures were evaluated on surgical postoperative sections that stained with hematoxylin and eosin staining.

resultsWe found that cell-in-cell structures associated with cancer-related mortality in univariable analysis with a hazard ratio (HR) of 2.99 (95%CI 1.52-5.88; P = 0.001). This association was confirmed in multivariable analysis (HR 2.22, 95%CI 1.12-4.44; P = 0.024). In addition, statistically significant associations were observed between the cell-in-cell structures and other adverse histopathologic characteristics including deep invasion (P <  0.001), high index of tumor budding (P = 0.007), worst pattern of invasion (P <  0.001), perineural invasion (P = 0.01), and stroma-rich pattern (P = 0.001).

conclusionsOur findings demonstrate a significant relationship between cell-in-cell formation and aggressive characteristics of early OTSCC. Cell-in-cell structures have a distinct impact as a novel prognostic indicator in early OTSCC and they can be easily assessed during routine pathology practice.

Indexed as

Cell-in-Cell FormationAgedBiomarkers, TumorBrazilCarcinoma, Squamous CellFemaleFinlandFollow-Up StudiesHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisProportional Hazards ModelsBiomarkers, TumorBiomarkersCell-in-cell formationMortalityTongue neoplasms

Identifiers

PMID32883229
PMCPMC7469910
OpenAlexW3081599083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.