Evidence map›Paper›PMID 32882843›Full record

ReviewInternational journal of molecular sciences2020

ApoE Lipidation as a Therapeutic Target in Alzheimer's Disease.

Maria Fe Lanfranco, Christi Anne Ng, G William Rebeck

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 1 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 1 synthesis or guideline pooled it, 186 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. The bidirectional mechanistic links between Alzheimer's disease and cardiovascular disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
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  17. Hologenomics Reveals Specialized Dietary Adaptations in the Mengla Snail-Eating Snake.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  18. Review
  19. Article
  20. Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Maria Fe LanfrancoDepartment of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA.
Christi Anne NgDepartment of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA.ORCID 0000-0003-0125-5921
G William RebeckDepartment of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA.ORCID 0000-0001-6276-248X
Georgetown University · US

Funding

APOE4 promotes pathogenesis in a mouse model of cancer chemotherapy-induced cognitive impairmentR01AG067258 · NIA · GEORGETOWN UNIVERSITY · PI REBECK, G WILLIAM · 2020 to 2024
$2.1M
APOE isoform affects protein structure and function in normal brainR01NS100704 · NINDS · GEORGETOWN UNIVERSITY · PI REBECK, G WILLIAM · 2017 to 2021
$2.0M
NIH HHS R01 AG067258NIH HHS R01 NS100704NINDS NIH HHS R01 NS100704
6 · The paper itself

Abstract

Apolipoprotein E (

Indexed as

Alzheimer DiseaseAnimalsApolipoproteins EHumansLipidsNeuroprotective AgentsApolipoproteins ELipidsNeuroprotective Agentsapolipoprotein Echolesterollipid homeostasisneurodegeneration

Identifiers

PMID32882843
PMCPMC7503657
OpenAlexW3081542127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.