Evidence map›Paper›PMID 32882836›Full record

ArticleMolecules (Basel, Switzerland)2020

Enhanced Antigiardial Effect of Omeprazole Analog Benzimidazole Compounds.

Beatriz Hernández-Ochoa, Saúl Gómez-Manzo, Adrián Sánchez-Carrillo, Jaime Marcial-Quino, Luz María Rocha-Ramírez, Araceli Santos-Segura, Edson Jiovany Ramírez-Nava, Roberto Arreguin-Espinosa, Miguel Cuevas-Cruz, Alfonso Méndez-Tenorio and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Ultrastructural Alterations of the Human PathogenPathogens (Basel, Switzerland) · 2023
    Review
  6. Article
  7. International journal of molecular sciences · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Beatriz Hernández-OchoaLaboratorio de Inmunoquímica, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Ciudad de Mexico 06720, Mexico.
Saúl Gómez-ManzoLaboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México 04530, Mexico.ORCID 0000-0003-2095-9182
Adrián Sánchez-CarrilloLaboratorio de Inmunoquímica, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Ciudad de Mexico 06720, Mexico.
Jaime Marcial-QuinoConsejo Nacional de Ciencia y Tecnología (CONACYT), Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de Mexico 04530, Mexico.ORCID 0000-0002-4591-7379
Luz María Rocha-RamírezUnidad de Investigación en Enfermedades Infecciosas, Hospital Infantil de México Federico Gómez, Secretaría de Salud Dr. Márquez No. 162, Col Doctores, Delegación Cuauhtémoc, Ciudad de México 06720, Mexico.ORCID 0000-0002-7204-1421
Araceli Santos-SeguraLaboratorio de Inmunoquímica, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Ciudad de Mexico 06720, Mexico.
Edson Jiovany Ramírez-NavaLaboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México 04530, Mexico.ORCID 0000-0002-1166-190X
Roberto Arreguin-EspinosaDepartamento de Química de Biomacromoléculas, Instituto de Química, Universidad Nacional Autónoma de Mexico, Ciudad de Mexico 04510, Mexico.ORCID 0000-0002-4611-4770
Miguel Cuevas-CruzDepartamento de Química de Biomacromoléculas, Instituto de Química, Universidad Nacional Autónoma de Mexico, Ciudad de Mexico 04510, Mexico.ORCID 0000-0001-9921-5930
Alfonso Méndez-TenorioLaboratorio de Biotecnología y Bioinformática Genómica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.ORCID 0000-0003-1871-4311
Ernesto Calderón-JaimesLaboratorio de Inmunoquímica, Hospital Infantil de México Federico Gómez, Secretaría de Salud, Ciudad de Mexico 06720, Mexico.
Secretaria de Salud · MXUniversidad Nacional Autónoma de México · MXInstituto Politécnico Nacional · MX

Funding

This research was funded by Fondos Federales, México. B.H.-O was funded by HIM/2017/100 SSA 1430 and L.M.R.-R by HIM/2014/013 SSA 1120, and by the E022 Program, National Institute of Pediatrics, Mexico City, Mexico (Recursos Fiscales para la Investigación S.G.-M. was supported by INP 038/2019. J.M.-Q. was supported by INP 024/2017, and by CONACYT grant 259201, Cátedras CONACYT (2184) project number 2057.
6 · The paper itself

Abstract

Giardiasis is a diarrheal disease that is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; however, failures in drug therapy are common, and have adverse effects and increased resistance of the parasite to the drug, generating the need to find new alternative treatments. In this study, we synthesized a series of 2-mercaptobenzimidazoles that are derivatives of omeprazole, and the chemical structures were confirmed through mass,

Indexed as

Antiprotozoal AgentsBenzimidazolesCaco-2 CellsCell DeathCell SurvivalCircular DichroismDrug DesignDrug Evaluation, PreclinicalEnzyme ActivationGiardia lambliaHT29 CellsHumansKineticsLansoprazoleMolecular Docking SimulationOmeprazoleAntiprotozoal AgentsbenzimidazoleBenzimidazolesLansoprazoleOmeprazoleTriose-Phosphate Isomerasegiardiacidal compoundsgiardiasisinhibition enzymeomeprazole analogs

Identifiers

PMID32882836
PMCPMC7504735
OpenAlexW3081882868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.