Evidence map›Paper›PMID 32882677›Full record

ArticleJournal of the mechanical behavior of biomedical materials2020

Tensile mechanical changes in the Achilles tendon due to Insertional Achilles tendinopathy.

Ibrahima Bah, Ninoshka R J Fernandes, Ruth L Chimenti, John Ketz, A Samuel Flemister, Mark R Buckley

Abstract read
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In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Tendon mechanical properties are enhancedFrontiers in bioengineering and biotechnology · 2022
    Article
  10. Article
  11. The effects of maturation and aging on the rotator cuff tendon-to-bone interface.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ibrahima BahUniversity of Rochester Department of Biomedical Engineering, United States. Electronic address: ibah@u.rochester.edu.
Ninoshka R J FernandesUniversity of Rochester Department of Biomedical Engineering, United States.
Ruth L ChimentiUniversity of Iowa Department of Physical Therapy and Rehabilitation Science, United States.
John KetzUniversity of Rochester Department of Orthopaedics, United States.
A Samuel FlemisterUniversity of Rochester Department of Orthopaedics, United States.
Mark R BuckleyUniversity of Rochester Department of Biomedical Engineering, United States. Electronic address: mark.buckley@rochester.edu.

Funding

Modulation of Insertional Achilles Tendinopathy by Multiaxial Mechanical StrainsR01AR070765 · NIAMS · UNIVERSITY OF ROCHESTER · PI BUCKLEY, MARK RAYMOND · 2017 to 2021
$1.7M
NIAMS NIH HHS R01 AR070765
6 · The paper itself

Abstract

Insertional Achilles tendinopathy (IAT) is a painful condition that is challenging to treat non-operatively. Although previous studies have characterized the gross histological features, in vivo strain patterns and transverse compressive mechanical properties of tissue affected by IAT, it is not known how IAT impacts the tensile mechanical properties of the Achilles tendon insertion along the axial/longitudinal direction (i.e., along the predominant direction of loading). To address this knowledge gap, the objectives of this study were to 1) apply ex vivo mechanical testing, nonlinear elastic analysis and quasilinear viscoelastic (QLV) analysis to compare the axial tensile mechanical properties of the Achilles tendon insertion in individuals with and without IAT; and 2) use biochemical analysis and second harmonic generation (SHG) imaging to assess structural and compositional changes induced by IAT in order to help explain IAT-associated tensile mechanical changes. Tissue from the Achilles tendon insertion was acquired from healthy donors and from patients undergoing debridement surgery for IAT. Tissue specimens were mechanically tested using a uniaxial tensile (stress relaxation) test applied in the axial direction. A subset of the donor specimens was used for SHG imaging and biochemical analysis. Linear and non-linear elastic analyses of the stress relaxation tests showed no significant tensile mechanical changes in IAT specimens compared to healthy controls. However, SHG analysis showed that fibrillar collagen was significantly more disorganized in IAT tissue as compared with healthy controls, and biochemical analysis showed that sulfated glycosaminoglycan (sGAG) content and water content were higher in IAT specimens. Collectively, these findings suggest that conservative interventions for IAT should target restoration of ultrastructural organization, reduced GAG content, and reduced resistance to transverse compressive strain.

Indexed as

Achilles TendonTendinopathyHumansAchilles tendonCollagenGlycosaminoglycansInsertional achilles tendinopathyQuasi-linear viscoelasticity (QLV)Tensile

Identifiers

PMID32882677
PMCPMC8056289

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.