Evidence map›Paper›PMID 32882393›Full record

SynthesisAnnals of hepatology

A systematic review and meta-analysis of the COVID-19 associated liver injury.

Yu Jun Wong, Malcolm Tan, Qishi Zheng, James Weiquan Li, Rahul Kumar, Kwong Ming Fock, Eng Kiong Teo, Tiing Leong Ang

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 7 pooled it
1.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 7 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Clinical significance of prognostic nutrition index in hospitalized patients with COVID-19: Results from single-center experience with systematic review and meta-analysis.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2021
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Article
  9. Review
  10. Article
  11. [Gastrointestinal manifestations and liver disorders in patients with COVID-19].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Observational
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Effect of SARS-CoV-2 infection on the liver.World journal of virology · 2023
    Review
  18. Article
  19. COVID-19 and liver injury in individuals with obesity.World journal of gastroenterology · 2023
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yu Jun WongDepartment of Gastroenterology and Hepatology, Changi General Hospital; Yong Loo Lin School of Medicine, National University of Singapore. Electronic address: eugene.wong.y.j@singhealth.com.sg.
Malcolm TanDepartment of Gastroenterology and Hepatology, Changi General Hospital; Yong Loo Lin School of Medicine, National University of Singapore.
Qishi ZhengSingapore Clinical Research Institute; Cochrane Singapore.
James Weiquan LiDepartment of Gastroenterology and Hepatology, Changi General Hospital; Yong Loo Lin School of Medicine, National University of Singapore.
Rahul KumarDepartment of Gastroenterology and Hepatology, Changi General Hospital.
Kwong Ming FockDepartment of Gastroenterology and Hepatology, Changi General Hospital; Yong Loo Lin School of Medicine, National University of Singapore; Cochrane Singapore.
Eng Kiong TeoDepartment of Gastroenterology and Hepatology, Changi General Hospital; Yong Loo Lin School of Medicine, National University of Singapore.
Tiing Leong AngDepartment of Gastroenterology and Hepatology, Changi General Hospital; Yong Loo Lin School of Medicine, National University of Singapore.
Changi General Hospital · SGNational University of Singapore · SGSingapore Clinical Research Institute · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION AND

objectivesThe novel coronavirus disease 2019 (COVID-19) has affected more than 5 million people globally. Data on the prevalence and degree of COVID-19 associated liver injury among patients with COVID-19 remain limited. We conducted a systematic review and meta-analysis to assess the prevalence and degree of liver injury between patients with severe and non-severe COVID-19.

methodsWe performed a systematic search of three electronic databases (PubMed/MEDLINE, EMBASE and Cochrane Library), from inception to 24

resultsAmong 1543 citations, there were 24 studies (5961 subjects) which fulfilled our inclusion criteria. The pooled odds ratio for elevated ALT (OR = 2.5, 95%CI: 1.6-3.7, I

conclusionCOVID-19 associated liver injury is more common in severe COVID-19 than non-severe COVID-19. Physicians should be aware of possible progression to severe disease in subjects with COVID-19-associated liver injury.

Indexed as

BetacoronavirusCoronavirus InfectionsCOVID-19HumansLiver DiseasesPandemicsPneumonia, ViralSARS-CoV-2Alanine TransaminaseAspartate AminotransferasesLiver DiseaseSARS-CoV-2 infection

Identifiers

PMID32882393
PMCPMC7458067
OpenAlexW3081689105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.