ArticleNeuroImage2020
Association of mid-life serum lipid levels with late-life brain volumes: The atherosclerosis risk in communities neurocognitive study (ARICNCS).
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Association of LDL cargo proteins with white matter hyperintensity volume in older adults from the atherosclerosis risk in communities study.Journal of Alzheimer's disease : JAD · 2026Article
- A simple nomogram to predict the onset of dementia in mild cognitive impairment: A retrospective study.Journal of Alzheimer's disease : JAD · 2025Article
- Atlas of plasma metabolic markers linked to human brain morphology.bioRxiv : the preprint server for biology · 2025Article
- Association of carotid atherosclerosis with brain tissue integrity and metabolic parameters in type 2 diabetes patients.Frontiers in endocrinology · 2025Article
- Associations of Triglycerides and Atherogenic Index of Plasma with Brain Structure in the Middle-Aged and Elderly Adults.Nutrients · 2024Article
- Sex differences in plasma lipid profiles of accelerated brain aging.Neurobiology of aging · 2023Article
- Brain volume, energy balance, and cardiovascular health in two nonindustrial South American populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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10 authors.
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Abstract
backgroundLimited information exists regarding the association between midlife lipid levels and late-life total and regional brain volumes.
methodsWe studied 1872 participants in the longitudinal community-based Atherosclerosis Risk in Communities Neurocognitive Study. Serum lipid levels were measured in 1987-1989 (mean age, 53 ± 5 years). Participants underwent 3T brain MRI scans in 2011-2013. Brain volumes were measured using FreeSurfer image analysis software. Linear regression models were used to assess the associations between serum lipids and brain volumes modeled in standard deviation (SD) units, adjusting for potential confounders.
resultsIn adjusted analyses, one SD higher low-density lipoprotein cholesterol (LDL) levels were associated with larger total brain volumes (β 0.033, 95% CI 0.006-0.060) as well as larger volumes of the temporal (β 0.038, 95% CI 0.003-0.074) and parietal lobes (β 0.044, 95% CI 0.009-0.07) and Alzheimer disease-related region (β 0.048, 95% CI 0.048-0.085). Higher triglyceride levels were associated with smaller total brain volumes (β -0.033, 95% CI -0.060, -0.007). The associations between LDL levels and brain volumes were modified by age (P for interaction <0.001), with higher LDL levels associated with larger total and regional brain volumes only among adults >53 years at baseline, and were attenuated after application of weights to account for informative attrition, although associations with the parietal and Alzheimer's disease-related region remained significant. High-density lipoprotein cholesterol was not associated with brain volumes.
conclusionHigher LDL levels in late midlife were associated with larger brain volumes later in life, while higher triglyceride levels were associated with smaller brain volumes. These associations were driven by adults >53 years at baseline.
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