Evidence map›Paper›PMID 32882157›Full record

ArticleHuman vaccines & immunotherapeutics2021

Immunization status and re-immunization of childhood acute lymphoblastic leukemia survivors.

Ersin Toret, Sumeyye Emel Yel, Murat Suman, Yeter Duzenli Kar, Zeynep Canan Ozdemir, Meltem Dinleyici, Ozcan Bor

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07422337 (Blinatumomab's Outcome On Serologic Titers and Efficacy of Revaccination), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07422337 recruitingnot on this mapstarted 2026, after this paper: background citation

Blinatumomab's Outcome On Serologic Titers and Efficacy of Revaccination

TypeobservationalSponsorArkansas Children's Hospital Research InstituteRan2026 to 2029Enrolled300ConditionsB-Cell ALL, B-Cell Acute Lymphoblastic Leukaemia, B-Cell Lymphoblastic Leukemia, B-Cell Lymphoblastic Leukemia/Lymphoma
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ersin ToretFaculty of Medicine, Department of Pediatric Hematology-Oncology, Eskisehir Osmangazi University, Eskisehir, Turkey.ORCID 0000-0002-6379-8326
Sumeyye Emel YelFaculty of Medicine, Department of Pediatric Hematology-Oncology, Eskisehir Osmangazi University, Eskisehir, Turkey.ORCID 0000-0002-2271-2776
Murat SumanFaculty of Medicine, Department of Pediatric Hematology-Oncology, Eskisehir Osmangazi University, Eskisehir, Turkey.ORCID 0000-0002-7078-9970
Yeter Duzenli KarFaculty of Medicine, Department of Pediatric Hematology-Oncology, Eskisehir Osmangazi University, Eskisehir, Turkey.ORCID 0000-0003-2917-7750
Zeynep Canan OzdemirFaculty of Medicine, Department of Pediatric Hematology-Oncology, Eskisehir Osmangazi University, Eskisehir, Turkey.ORCID 0000-0002-9172-9627
Meltem DinleyiciFaculty of Medicine, Department of Social Pediatrics, Eskisehir Osmangazi University, Eskisehir, Turkey.ORCID 0000-0002-0339-0134
Ozcan BorFaculty of Medicine, Department of Pediatric Hematology-Oncology, Eskisehir Osmangazi University, Eskisehir, Turkey.ORCID 0000-0002-1662-3259
Eskişehir Osmangazi University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intensive chemotherapy can cause long-lasting immunosuppression in children who survived cancer. The immunosuppression varies according to the type of cancer, intensity of chemotherapy and age of the patient. A sufficient immune reconstruction when has been completed in childhood cancer survivors, the re-vaccination program can achieve sufficient antibody levels for some of the life-threatening vaccine-preventable infectious diseases. This study evaluates the serological status of pediatric acute lymphoblastic leukemia (ALL) cases before and after the intensive chemotherapy treatment. Antibodies against measles, mumps, rubella, varicella, hepatitis A and B were tested with the enzyme-linked immunosorbent assay (ELISA) method. Antibody titers were measured firstly at the leukemia diagnosis time when the chemotherapy was not started. The second evaluation of antibody titers was studied at 6 months after the cessation of chemotherapy for all patients. Forty-six patients with the mean age of 6.1 ± 4.5 years were participated in this study. Changing to seronegative after treatment was significantly different in measles, rubella, hepatitis A and hepatitis B (

Indexed as

MeaslesMumpsPrecursor Cell Lymphoblastic Leukemia-LymphomaRubellaAntibodies, ViralChildChild, PreschoolHumansImmunizationInfantMeasles-Mumps-Rubella VaccineSurvivorsVaccinationAntibodies, ViralMeasles-Mumps-Rubella VaccinecancerChildhoodimmunityleukemiasurvivorsvaccination

Identifiers

PMID32882157
PMCPMC8018341
OpenAlexW3083528178

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.