ArticleArthritis care & research2022
Association of Pain Sensitization and Conditioned Pain Modulation to Pain Patterns in Knee Osteoarthritis.
Article in Arthritis care & research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- An overview of systematic reviews examining the quantitative sensory testing-derived hypoalgesic effects of manual therapy for musculoskeletal pain.The Journal of manual & manipulative therapy · 2024Pooled it
- Myofascial Trigger Point-Augmented Acupuncture vs Conventional Acupuncture for Early- to Mid-Stage Knee Osteoarthritis: A Randomized Clinical Trial.Journal of pain research · 2026Trial
- Positive Preemptive Analgesia Effectiveness of Pregabalin Combined with Celecoxib in Total Knee Arthroplasty: A Prospective Controlled Randomized Study.Pain research & management · 2023Trial
- Does pain pattern matter? Association of intermittent, constant, predictable and unpredictable knee pain to patient-reported knee symptom acceptability in knee osteoarthritis.Osteoarthritis and cartilage open · 2026Article
- Factors Associated With Intermittent and Constant Pain Patterns in People With Gout: A Cross-Sectional Analysis.ACR open rheumatology · 2026Article
- Understanding Pain in Osteoarthritis: A Clinical Framework Based on the Biopsychosocial Model.Topics in geriatric rehabilitation · 2026Article
- Associations of Arterial Blood Pressure With Radiographic Knee Osteoarthritis and Pain Sensitivity in Middle-Aged and Older Adults.European journal of pain (London, England) · 2026Article
- Evoked temporal summation in dogs to assess pain central sensitization and modulation - A feasibility study.PloS one · 2026Article
- Association between constant and intermittent knee pain and T2 values and cartilage thickness: data from the osteoarthritis initiative.Arthritis research & therapy · 2025Article
- Association of different pain patterns with physical function in participants with knee osteoarthritis: data from the osteoarthritis initiative.Journal of orthopaedic surgery and research · 2025Article
- Antidepressants to Manage Osteoarthritic Pain: The Value of Pain Phenotyping.Drugs & aging · 2025Review
- A Mediation Appraisal of Neuropathic-like Symptoms, Pain Catastrophizing, and Central Sensitization-Related Signs in Adults with Knee Osteoarthritis-A Cross-Sectional Study.Journal of personalized medicine · 2025Article
- Associations of pain sensitivity and conditioned pain modulation with physical activity: findings from the Multicenter Osteoarthritis Study (MOST).Osteoarthritis and cartilage · 2024Observational
- Article
- Exploring different models of pain phenotypes and their association with pain worsening in people with early knee osteoarthritis: The MOST cohort study.Osteoarthritis and cartilage · 2024Article
- Suppression of CGRP and TRPV1 Expression in Dorsal Root Ganglia of Knee Osteoarthritis Rats by Huojing Decoction via TrkA/MKK3/6/p38 Pathway.Journal of inflammation research · 2024Article
- The Natural History of Knee Osteoarthritis Pain Experience and Risk Profiles.The journal of pain · 2023Observational
- Functional and Neural Correlates Associated with Conditioned Pain Modulation in Patients with Chronic Knee Osteoarthritis Pain: A Cross-Sectional Study.Life (Basel, Switzerland) · 2023Article
- Relation of pain sensitization to self-reported and performance-based measures of physical functioning: the Multicenter Osteoarthritis (MOST) study.Osteoarthritis and cartilage · 2023Article
- Neuropathic-like symptoms and central sensitization related signs and symptoms negatively affect the functional performance of patients with knee osteoarthritis - a cross-sectional study.Osteoarthritis and cartilage open · 2023Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo examine the cross-sectional association of ascending pain mechanisms, implicated in pain sensitization, and descending pain modulation with pain patterns and unpredictability of pain.
methodsThe Multicenter Osteoarthritis Study is a longitudinal cohort of older adults with or at risk of knee osteoarthritis. Peripheral and central ascending pain mechanisms were assessed using quantitative sensory tests, pressure pain thresholds using a handheld pressure algometer (knee/peripheral and wrist/central), and temporal summation using weighted probes (wrist/central). Descending modulation was assessed by conditioned pain modulation using pressure pain thresholds and a forearm ischemia test. Pain patterns were characterized based on responses to the Intermittent and Constant Osteoarthritis Pain questionnaire: 1) no intermittent or constant pain, 2) intermittent pain only, 3) constant pain only, and 4) combined constant and intermittent pain. A question regarding frequency assessed unpredictable pain. We assessed the association of quantitative sensory test measures to pain patterns using regression models with generalized estimating equations.
resultsThere were 2,794 participants (mean age 63.9 years, body mass index 29.5 kg/m
conclusionKnee pain patterns appear to be related to peripheral ± central facilitated ascending pain mechanisms and descending modulatory mechanisms. These findings highlight the need for a broader approach to understanding pain mechanisms by symptomatic disease progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.