ArticlePloS one2020
Renal hyperfiltration as a risk factor for chronic kidney disease: A health checkup cohort study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Glomerular hyperfiltration defined by eGFR and long-term clinical outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Young adults born moderately to extremely preterm have higher eGFR and cystatin C compared to young adults born at term.Pediatric nephrology (Berlin, Germany) · 2026Article
- Nutrition and Green Nephrology-not only for health but also for compensation: the water footprint and its hamburger equivalent.Clinical kidney journal · 2026Review
- The aging-related GFR decline in Chinese healthy elderly.International urology and nephrology · 2026Article
- The role of endothelin receptor antagonists in kidney disease.Renal failure · 2025Review
- Estimation of age and sex-specific Glomerular Filtration Rate and its association with mortality and atherosclerotic cardiovascular outcomes in the Abu Dhabi population; A Retrospective Cohort Study.Journal of nephrology · 2025Article
- Assessing the impact of supervised interval training on cardiovascular autonomic neuropathy in type 2 diabetes patients.Physiological reports · 2025Article
- Protein and Aging: Practicalities and Practice.Nutrients · 2025Review
- Relationship between bmi and glomerular filtration rate in a large cohort initiating a weight loss program: differential contributions of fat mass, fat-free mass, and abdominal fat compartments.Nutrition journal · 2025Article
- Calculation of Integral Indicators of the Metabolic Status and Filtration Function of Kidneys in Patients with a Combat Mine-Explosive Injury who Lost Significant Body Weight due to Limb Amputation.Acta medica Lituanic · 2025Article
- Role of Melatonin as an Adjunctive Treatment for Depression and Cognitive Impairment in Hemodialysis Patients: A Randomized, Double-Blind Clinical Trial.Iranian journal of psychiatry · 2025Article
- Sodium Glucose Cotransporter-2 Inhibitors in Non-Diabetic Kidney Disease: Evidence in Experimental Models.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Protein supplementation: the double-edged sword.Proceedings (Baylor University. Medical Center) · 2024Review
- The association between renal hyperfiltration and mortality is not mediated by diabetes mellitus.International urology and nephrology · 2023Article
- Glomerular hyperfiltration: part 2-clinical significance in children.Pediatric nephrology (Berlin, Germany) · 2023Review
- Clinical features and risk factors of renal dysfunctions in thalassemic patients.International urology and nephrology · 2023Article
- Prediction tool for renal adaptation after living kidney donation using interpretable machine learning.Frontiers in medicine · 2023Article
- Estimated glomerular filtration rate trajectories in south Asians: Findings from the cardiometabolic risk reduction in south Asia study.The Lancet regional health. Southeast Asia · 2022Article
- Polygenic association of glomerular filtration rate decline in world trade center responders.BMC nephrology · 2022Article
- Mortality-based definition of renal hyperfiltration in middle-aged men: a 35-year cohort from Finland.International urology and nephrology · 2022Article
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Authors and funding
5 authors.
Funding
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Abstract
introductionRenal hyperfiltration (RHF) has been found to be an independent predictor of adverse cardiovascular outcome. However, it remains uncertain whether it is precursor of chronic kidney disease (CKD) in a healthy population. MATERIALS AND
methodsTo determine relative risks and identify the predictor of incident proteinuria and decline of estimated glomerular filtration rate (eGFR) in subjects with RHF. A total of 55,992 subjects aged ≥20 years who underwent health check-up during 2004-2017 were included. Among them, 16,946 subjects who completed at least two health checkups were analyzed.
resultsA total of 949 (5.6%) subjects developed proteinuria and 98 (0.6%) subjects showed ≥ 30% of eGFR decline. The risk of incident proteinuria was significantly higher in those with RHF (RR: 1.644; 95% CI: 1.064-2.541). Those with RHF showed 8.720 fold (95% CI: 4.205-18.081) increased risk for ≥30% decline. ESR, CRP, and monocyte count showed reversed J shaped curve according to the increase of eGFR. The adjusted mean of monocyte count was significantly higher in participants with eGFR ≥90ml/min/1.73m2 or < 60ml/min/1.73m2 compared to that in patients with eGFR 75-89ml/min/1.73m2. Compared to subjects with the lowest tertile of monocyte and no RHF, those with the highest tertile of monocyte count in the RHF group had 3.314-fold (95% CI: 1.893-5.802) higher risk of incident proteinuria and 3.822-fold (95% CI, 1.327-11.006) risk of 30% eGFR decline.
conclusionsRHF had significantly increased risk of developing proteinuria and CKD in healthy subjects. Higher monocyte count might be used as a predictor of CKD in subjects with RHF.
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