Evidence map›Paper›PMID 32881620›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2020

A novel ex vivo protocol to mimic human walking gait: implications for Duchenne muscular dystrophy.

Katherine E Bukovec, Xiao Hu, Matthew Borkowski, Duane Jeffery, Silvia S Blemker, Robert W Grange

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A novel murine muscle loading model to investigate Achilles musculotendinous adaptation.Journal of applied physiology (Bethesda, Md. : 1985) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Katherine E BukovecDepartment of Human Nutrition, Foods, and Exercise and Metabolism Core, Virginia Tech, Blacksburg, Virginia.
Xiao HuDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
Matthew BorkowskiAurora Scientific, Inc., Aurora, Ontario, Canada.
Duane JefferyAurora Scientific, Inc., Aurora, Ontario, Canada.
Silvia S BlemkerDepartment of Biomedical Engineering, University of Virginia, Charlottesville, Virginia.
Robert W GrangeDepartment of Human Nutrition, Foods, and Exercise and Metabolism Core, Virginia Tech, Blacksburg, Virginia.
Aurora College · CAUniversity of Virginia · USVirginia Tech · US

Funding

Multiscale Modeling for Treatment Discovery in Duchenne Muscular DystrophyU01AR069393 · NIAMS · UNIVERSITY OF VIRGINIA · PI BLEMKER, SILVIA SALINAS, PEIRCE-COTTLER, SHAYN · 2016 to 2020
$2.5M
NIAMS NIH HHS U01 AR069393NIH HHS UO1 1U01AR069393
6 · The paper itself

Abstract

We developed a novel ex vivo mouse protocol to mimic in vivo human soleus muscle function predicted by musculoskeletal simulations to better understand eccentric contractions during gait and ultimately to better understand their effects in Duchenne muscular dystrophy (DMD) muscles. DMD muscles are susceptible to eccentric injury because the protein dystrophin is absent. The

Indexed as

Muscular Dystrophy, DuchenneAnimalsGaitHumansMiceMice, Inbred mdxMuscle ContractionMuscle, SkeletalWalkingdystrophyeccentricfunctiongaitskeletal muscle

Identifiers

PMID32881620
PMCPMC7654698
OpenAlexW3083144920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.