Evidence map›Paper›PMID 32881483›Full record

ArticleACS chemical biology2020

A Single Amino Acid Determines the Selectivity and Efficacy of Selective Negative Allosteric Modulators of Ca

Garry Cooper, Soosung Kang, Tamara Perez-Rosello, Jaime N Guzman, Daniel Galtieri, Zhong Xie, Jyothisri Kondapalli, Jack Mordell, Richard B Silverman, D James Surmeier

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. The L-type calcium channel CaV1.3: A potential target for cancer therapy.Journal of cellular and molecular medicine · 2024
    Review
  3. Article
  4. Article
  5. CaBritish journal of pharmacology · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Voltage-Gated CaFrontiers in synaptic neuroscience · 2021
    Review
  12. The Involvement of CaFrontiers in neural circuits · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Garry CooperDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, United States.
Soosung KangDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, United States.ORCID 0000-0001-7016-2417
Tamara Perez-RoselloDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.
Jaime N GuzmanDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.
Daniel GaltieriDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.
Zhong XieDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.
Jyothisri KondapalliDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.
Jack MordellDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.
Richard B SilvermanDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, United States.ORCID 0000-0001-9034-1084
D James SurmeierDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States.
Northwestern University · US

Funding

SYNAPTIC CONTROLOF PALLIDAL ACTIVITYP50NS047085 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SURMEIER, DALTON JAMES · 2003 to 2018
$19.2M
A novel calcium channel antagonist for neuroprotection in Parkinson???s diseaseU01NS080409 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SURMEIER, DALTON JAMES · 2012 to 2013
$193k
NINDS NIH HHS P50 NS047085NINDS NIH HHS U01 NS080409
6 · The paper itself

Abstract

Ca

Indexed as

Allosteric RegulationAllosteric SiteAnimalsCalciumCalcium Channel BlockersCalcium Channels, L-TypeDopaminergic NeuronsHEK293 CellsHumansMiceMolecular Docking SimulationMutagenesis, Site-DirectedMutationProtein BindingPyrimidinonesRabbitsCACNA1D protein, humanCalciumCalcium Channel BlockersCalcium Channels, L-TypePyrimidinones

Identifiers

PMID32881483
PMCPMC7502546
OpenAlexW3083676054

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.