ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020
Effects of bilingualism on age at onset in two clinical Alzheimer's disease variants.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05741853 (Cognitive Reserve and Linguistic Resilience in Bilingual Hispanics With Primary Progressive Aphasia), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cognitive Reserve and Linguistic Resilience in Bilingual Hispanics With Primary Progressive Aphasia
Who cites it
18 citing papers in PubMed.
- Reported symptoms and patterns of language impairment in bilingual speakers with primary progressive aphasia: a retrospective study.Aphasiology · 2026Article
- Language, Immigration, Race and Cognitive Health: Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study.Journal of racial and ethnic health disparities · 2026Article
- Bilingualism's protective effects in Alzheimer's disease: Mechanisms of resilience and resistance.medRxiv : the preprint server for health sciences · 2026Article
- Evidence for bilingualism as a cognitive reserve factor in biomarker-confirmed Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
- Cognitive and brain reserve in bilingual speakers with clinical AD variants.medRxiv : the preprint server for health sciences · 2026Article
- Selective cognitive effects of multilingualism emerge in visuospatial working memory in later life.Scientific reports · 2025Article
- The role of bilingualism on functional decline and neurodegeneration in distinct ADRD clinical syndromes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The influence of bilingualism on the assessment and treatment of an Italian-English speaker with the logopenic variant of PPA.Research square · 2025Article
- Language disorders in understudied languages: Opening editorial.Cortex; a journal devoted to the study of the nervous system and behavior · 2025Article
- Bilingualism modifies cognition through adaptation, not transfer.Trends in cognitive sciences · 2024Review
- Examining the relation between bilingualism and age of symptom onset in frontotemporal dementia.Bilingualism (Cambridge, England) · 2024Article
- Bilingualism and Structural Network Organization in Temporal Lobe Epilepsy: Resilience in Neurologic Disease.Neurology · 2023Observational
- Bilingual Primary Progressive Aphasia: A Scoping Review of Assessment and Treatment Practices.Journal of Alzheimer's disease : JAD · 2023Article
- Bilingualism and Aging: Implications for (Delaying) Neurocognitive Decline.Frontiers in human neuroscience · 2022Review
- Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.Current neurology and neuroscience reports · 2021Review
- Bilingualism: A Global Public Health Strategy for Healthy Cognitive Aging.Frontiers in neurology · 2021Article
- Frontotemporal dementia in Hispanic populations: Regional and national comparisons.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- The influence of bilingualism on the assessment and treatment of an Italian-English speaker with the logopenic variant of PPA.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
introductionThe effect of bilingualism on age at onset has yet to be examined within different clinical variants of Alzheimer's disease.
methodsWe reviewed the research charts of 287 well-characterized participants with either amnestic Alzheimer's dementia or logopenic variant primary progressive aphasia (lvPPA) and identified bilingual speakers based on regular use of two or more languages and/or ability to communicate with native speakers in two or more languages. We evaluated whether bilingual speakers demonstrated a delay in age of symptom onset relative to monolingual speakers while controlling for other variables known to influence cognitive reserve.
resultsA 5-year delay in age at symptom onset was observed for bilingual relative to monolingual speakers with lvPPA. This delay in onset was not observed in the amnestic Alzheimer's dementia cohort. DISCUSSION: Bilingualism may serve as a unique cognitive reserve variable in lvPPA, but not in amnestic Alzheimer's dementia.
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