ArticleCNS neuroscience & therapeutics2020
Dopamine neurons in the ventral periaqueductal gray modulate isoflurane anesthesia in rats.
Article in CNS neuroscience & therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 33 citations in OpenAlex.
- Role of Dorsomedial Periaqueductal Gray Glutamatergic Neurons in Promoting Arousal under Multiple General Anesthetics in Mice.Anesthesiology · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- Neural Circuit Mechanisms of General Anaesthesia Induction: Current Advances and Future Directions.Current neuropharmacology · 2026Review
- Modulatory mechanism of the paraventricular thalamus (PVT) under general anesthesia.Frontiers in pharmacology · 2026Review
- Current and Developing Approaches for Facilitating Emergence from General Anesthesia.Anesthesiology · 2025Review
- Zingerone alleviates inflammatory pain by reducing the intrinsic excitability of anterior cingulate cortex neurons in a mice model.Frontiers in pharmacology · 2025Article
- Functional neuroanatomy of dopaminergic arousal systems: implications for the wake-promoting effect of psychostimulants, with particular reference to modafinil.Frontiers in neuroanatomy · 2025Review
- Neural Network Mechanisms Underlying General Anesthesia: Cortical and Subcortical Nuclei.Neuroscience bulletin · 2024Review
- Zona Incerta GABAergic Neurons Facilitate Emergence from Isoflurane Anesthesia in Mice.Neurochemical research · 2024Article
- Glutamatergic neurons of piriform cortex delay induction of inhalational general anesthesia.Fundamental research · 2024Article
- Article
- The contribution of periaqueductal gray in the regulation of physiological and pathological behaviors.Frontiers in neuroscience · 2024Review
- Dopaminergic modulation of propofol-induced activation in VLPO neurons: the role of D1 receptors in sleep-promoting neural circuits.Frontiers in neuroscience · 2024Article
- Dopamine D1-receptor-expressing pathway from the nucleus accumbens to ventral pallidum-mediated sevoflurane anesthesia in mice.CNS neuroscience & therapeutics · 2023Article
- Dopaminergic System in Promoting Recovery from General Anesthesia.Brain sciences · 2023Review
- Claustrum modulates behavioral sensitivity and EEG activity of propofol anesthesia.CNS neuroscience & therapeutics · 2023Article
- Glutamatergic neurons in paraventricular nucleus of the thalamus regulate the recovery from isoflurane anesthesia.BMC anesthesiology · 2022Article
- Regulation of Neural Circuitry under General Anesthesia: New Methods and Findings.Biomolecules · 2022Review
- The Aged Striatum: Evidence of Molecular and Structural Changes Using a Longitudinal Multimodal Approach in Mice.Frontiers in aging neuroscience · 2022Article
- Dorsal raphe serotonergic neurons promote arousal from isoflurane anesthesia.CNS neuroscience & therapeutics · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsGeneral anesthesia has been applied in surgery for more than 170 years, and there is little doubt that GABA
methodsIn the present study, we used calcium fiber photometry recording to explore that the activity of ventral periaqueductal gray (vPAG) neurons. Then, rats were unilaterally microinjected with 6-hydroxydopamine into the vPAG area to determine the role of vPAG-DA neurons in isoflurane-induced-anesthesia. Furthermore, thirty SD rats were divided into three groups: a GABA
resultsThe vPAG neurons were markedly inhibited during isoflurane anesthesia induction and that these neurons were activated during emergence from isoflurane anesthesia. Lesion to the vPAG-DA neurons shortened the induction time and prolonged the emergence time while increasing δ power in isoflurane anesthesia. Intracerebral injection of the GABA
conclusionOur results suggest that vPAG-DA neurons are involved in isoflurane anesthesia through activation of the GABA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.