Evidence map›Paper›PMID 32881298›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020

A cross-national study of depression in preclinical dementia: A COSMIC collaboration study.

Sophie Carles, Isabelle Carrière, Simone Reppermund, Annalisa Davin, Antonio Guaita, Roberta Vaccaro, Mary Ganguli, Erin P Jacobsen, Joanne C Beer, Steffi G Riedel-Heller and 17 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Artificial intelligence for dementia prevention.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 16 institutions in 8 countries.

Sophie CarlesNeuropsychiatry: Epidemiological and Clinical Research, INSERM, Montpellier University, Montpellier, France.
Isabelle CarrièreNeuropsychiatry: Epidemiological and Clinical Research, INSERM, Montpellier University, Montpellier, France.
Simone ReppermundCentre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Annalisa DavinGolgi Cenci Foundation, Milan, Italy.
Antonio GuaitaGolgi Cenci Foundation, Milan, Italy.
Roberta VaccaroGolgi Cenci Foundation, Milan, Italy.
Mary GanguliDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Erin P JacobsenDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Joanne C BeerDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Steffi G Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, Medical Faculty, University of Leipzig, Leipzig, Germany.
Susanne RoehrDepartment of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, California, USA.
Alexander PabstDepartment of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco, California, USA.
Mary N HaanDementia Collaborative Research Centre, University of New South Wales, Sydney, New South Wales, Australia.
Henry BrodatyDepartment of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia.
Nicole A KochanCentre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Julian N TrollorCentre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Ki Woong KimDepartment of Psychiatry, College of Medicine, Seoul National University, Seoul, South Korea.
Ji Won HanDepartment of Psychiatry, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea.
Seung Wan SuhDepartment of Medicine and Psychiatry, Universidad de Zaragoza, Zaragoza, Spain.
Antonio LoboCentro de Investigación Biomédica en Red de Salud Mental, Ministry of Science and Innovation, Madrid, Spain.
Concepción De la CamaraCentro de Investigación Biomédica en Red de Salud Mental, Ministry of Science and Innovation, Madrid, Spain.
Elena LoboInstitute of Social Medicine, Occupational Health and Public Health, Medical Faculty, University of Leipzig, Leipzig, Germany.
Darren M LipnickiCentre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Perminder S SachdevCentre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Marie-Laure AncelinNeuropsychiatry: Epidemiological and Clinical Research, INSERM, Montpellier University, Montpellier, France.
Karen RitchieNeuropsychiatry: Epidemiological and Clinical Research, INSERM, Montpellier University, Montpellier, France.
for Cohort Studies of Memory in an International Consortium (COSMIC)
UNSW Sydney · AUFondazione Golgi Cenci · ITUniversidad de Zaragoza · ESUniversité de Montpellier · FRUniversity of Pittsburgh · USCentro de Investigación Biomédica en Red de Salud Mental · ESHallym University · KRHospital Clínico Universitario Lozano Blesa · ESInserm · FRLeipzig University · DENeuropsychiatrie : Recherche Epidemiologique et Clinique · FRSeoul National University · KRUniversity of California, San Francisco · USUniversity of California System · USUniversity of Edinburgh · GBUniversity of Pennsylvania · US

Funding

Mild Cognitive Impairment: A Prospective Community StudyR01AG023651 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GANGULI, MARY · 2005 to 2020
$27.1M
EPIDEMIOLOGY OF FUNCTIONAL STATUS IN ELDERLY HISPANICSR01AG012975 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAAN, MARY N · 1997 to 2015
$13.8M
COSMIC: An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethno-racial groups and geographical settingsRF1AG057531 · NIA · UNIVERSITY OF NEW SOUTH WALES · PI SACHDEV, PERMINDER S · 2017 to 2020
$2.9M
NIA NIH HHS R01 AG012975NIA NIH HHS R01 AG023651NIA NIH HHS RF1 AG057531
6 · The paper itself

Abstract

introductionDepression commonly accompanies Alzheimer's disease, but the nature of this association remains uncertain.

methodsLongitudinal data from the COSMIC consortium were harmonized for eight population-based cohorts from four continents. Incident dementia was diagnosed in 646 participants, with a median follow-up time of 5.6 years to diagnosis. The association between years to dementia diagnosis and successive depressive states was assessed using a mixed effect logistic regression model. A generic inverse variance method was used to group study results, construct forest plots, and generate heterogeneity statistics.

resultsA common trajectory was observed showing an increase in the incidence of depression as the time to dementia diagnosis decreased despite cross-national variability in depression rates. DISCUSSION: The results support the hypothesis that depression occurring in the preclinical phases of dementia is more likely to be attributable to dementia-related brain changes than environment or reverse causality.

Indexed as

Prodromal SymptomsAgedAged, 80 and overCohort StudiesDementiaDepressionFemaleHumansIncidenceLongitudinal StudiesMaledementiadepressionincidence

Identifiers

PMID32881298
PMCPMC7666102
OpenAlexW3083569693

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.