Evidence map›Paper›PMID 32881211›Full record

ReviewChembiochem : a European journal of chemical biology2021

Activity-Based Protein Profiling (ABPP) of Oxidoreductases.

Rita Fuerst, Rolf Breinbauer

Abstract readReview
In one paragraph

Review in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Activity-Based Protein Profiling of Bacterial Monooxygenases.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. AlphaFold2 and its applications in the fields of biology and medicine.Signal transduction and targeted therapy · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Activity-Based Protein Profiling (ABPP) of Oxidoreductases.Chembiochem : a European journal of chemical biology · 2021
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rita FuerstInstitute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010, Graz, Austria.
Rolf BreinbauerInstitute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010, Graz, Austria.ORCID 0000-0001-6009-7359

Funding

NAWI Graz
6 · The paper itself

Abstract

Over the last two decades, activity-based protein profiling (ABPP) has been established as a tremendously useful proteomic tool for measuring the activity of proteins in their cellular context, annotating the function of uncharacterized proteins, and investigating the target profile of small-molecule inhibitors. Unlike hydrolases and other enzyme classes, which exhibit a characteristic nucleophilic residue, oxidoreductases have received much less attention in ABPP. In this minireview, the state of the art of ABPP of oxidoreductases is described and the scope and limitations of the existing approaches are discussed. It is noted that several ABPP probes have been described for various oxidases, but none so far for a reductase, which gives rise to opportunities for future research.

Indexed as

Drug DiscoveryAnimalsHumansOxidoreductasesProteomeSmall Molecule LibrariesOxidoreductasesProteomeSmall Molecule Librarieschemical proteomicscovalent inhibitorsdrug discoveryoxidoreductasesproteomics

Identifiers

PMID32881211
PMCPMC7894341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.