Evidence map›Paper›PMID 32880981›Full record

ArticleAlcoholism, clinical and experimental research2020

The Neurophysiology of Implicit Alcohol Associations in Recently Abstinent Patients With Alcohol Use Disorder: An Event-Related Potential Study Considering Gender Effects.

Raphaela Martina Tschuemperlin, Hallie Margareta Batschelet, Franz Moggi, Thomas Koenig, Susanne Roesner, Anne Keller, Philippe Pfeifer, Leila Maria Soravia, Maria Stein

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcoholism, clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Raphaela Martina TschuemperlinFrom the, Translational Research Center, (RMT, HMB, FM, TK, PP, LMS, MS), University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.ORCID 0000-0002-4423-0620
Hallie Margareta BatscheletFrom the, Translational Research Center, (RMT, HMB, FM, TK, PP, LMS, MS), University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.ORCID 0000-0001-9140-3371
Franz MoggiFrom the, Translational Research Center, (RMT, HMB, FM, TK, PP, LMS, MS), University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.ORCID 0000-0003-3302-7229
Thomas KoenigFrom the, Translational Research Center, (RMT, HMB, FM, TK, PP, LMS, MS), University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.ORCID 0000-0002-1472-4638
Susanne RoesnerAddiction Treatment Center, (SR, AK), Forel Clinic, Ellikon an der Thur, Switzerland.
Anne KellerAddiction Treatment Center, (SR, AK), Forel Clinic, Ellikon an der Thur, Switzerland.
Philippe PfeiferFrom the, Translational Research Center, (RMT, HMB, FM, TK, PP, LMS, MS), University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Leila Maria SoraviaFrom the, Translational Research Center, (RMT, HMB, FM, TK, PP, LMS, MS), University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.ORCID 0000-0002-4924-7771
Maria SteinFrom the, Translational Research Center, (RMT, HMB, FM, TK, PP, LMS, MS), University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.ORCID 0000-0002-7458-1982
University of Bern · CHForel Klinik · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuroscientific models of alcohol use disorders (AUDs) postulate an imbalance between automatic, implicit, and controlled (conscious) processes. Implicit associations towards alcohol indicate the automatically attributed appeal of alcohol-related stimuli. First, behavioral studies indicate that negative alcohol associations are less pronounced in patients compared to controls, but potential neurophysiological differences remain unexplored. This study investigates neurophysiological correlates of implicit alcohol associations in recently abstinent patients with AUD for the first time, including possible gender effects.

methodsA total of 62 patients (40 males and 22 females) and 21 controls performed an alcohol valence Implicit Association Test, combining alcohol-related pictures with positive (incongruent condition) or negative (congruent condition) words, while brain activity was recorded using 64-channel electroencephalography. Event-related potentials (ERPs) for alcohol-negative and alcohol-positive trials were computed. Microstate analyses investigated the effects of group (patients, controls) and condition (incongruent, congruent); furthermore, possible gender effects in patients were analyzed. Significant effects were localized with standardized low-resolution brain electromagnetic topography analysis.

resultsAlthough no behavioral group differences were found, ERPs of patients and controls were characterized by distinct microstates from 320 ms onwards. ERPs between conditions differed only in patients with higher signal strength during incongruent trials. Around 600 ms, controls displayed higher signal strength than patients. A gender effect mirrored this pattern with enhanced signal strength in females as opposed to male patients. Around 690 ms, a group-by-valence interaction indicated enhanced signal strength in congruent compared to incongruent trials, which was more pronounced in controls.

conclusionsFor patients with AUD, the pattern, timing, and source localization of effects suggest greater effort regarding semantic and self-relevant integration around 400 ms during incongruent trials and attenuated emotional processing during the late positive potential timeframe. Interestingly, this emotional attenuation seemed reduced in female patients, thus corroborating the importance of gender-sensitive research and potential treatment of AUD.

Indexed as

Alcohol AbstinenceAdolescentAdultAlcoholismBrainCase-Control StudiesElectroencephalographyEvoked PotentialsFemaleHumansMaleMiddle AgedSex FactorsYoung AdultAlcohol Use DisorderEvent-Related PotentialsGenderImplicit Association TestMicrostates

Identifiers

PMID32880981
PMCPMC7693094
OpenAlexW3081876088

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.