Evidence map›Paper›PMID 32880925›Full record

ReviewImmunology2021

Candida albicans and candidalysin in inflammatory disorders and cancer.

Jemima Ho, Giorgio Camilli, James S Griffiths, Jonathan P Richardson, Nessim Kichik, Julian R Naglik

Open access · hybridAbstract readReview
In one paragraph

Review in Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Worldwide trend in research onFrontiers in microbiology · 2024
    Pooled it
  2. Trial
  3. Article
  4. Disruption of thePathogens (Basel, Switzerland) · 2026
    Article
  5. Article
  6. Article
  7. International journal of molecular sciences · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Complexities ofDentistry journal · 2025
    Review
  12. Review
  13. Article
  14. Evaluating the Role ofInterdisciplinary perspectives on infectious diseases · 2025
    Review
  15. Rapid and simple detection ofFrontiers in cellular and infection microbiology · 2025
    Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jemima HoCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.ORCID 0000-0002-2356-9190
Giorgio CamilliCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
James S GriffithsCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
Jonathan P RichardsonCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
Nessim KichikCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
Julian R NaglikCentre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
King's College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/N014677/1Department of Health IS-BRC-1215-20006Medical Research Council MC_PC_16048NIH HHS R37-DE022550The Wellcome Trust 214229 Z 18 Z
6 · The paper itself

Abstract

As our understanding of mycology progresses, the impact of fungal microbes on human health has become increasingly evident. Candida albicans is a common commensal fungus that gives rise to local and systemic infections, particularly in immunocompromised patients where it can result in mortality. However, C. albicans has also been quietly linked with a variety of inflammatory disorders, to which it has traditionally been considered incidental; recent studies may now provide new aspects of these relationships for further consideration. This review provides a novel perspective on the impact of C. albicans and its peptide toxin, candidalysin, on human health, exploring their contributions to pathology within a variety of diseases.

Indexed as

AnimalsCandida albicansCandidiasisFungal ProteinsHumansInflammationNeoplasmsECE1 protein, Candida albicansFungal ProteinsCandida albicanscandidalysingut barrierIL-17mucosal disease

Identifiers

PMID32880925
PMCPMC7730014
OpenAlexW3081812764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.