Evidence map›Paper›PMID 32880863›Full record

ArticleScience China. Life sciences2021

Structure of SARS-CoV-2 main protease in the apo state.

Xuelan Zhou, Fanglin Zhong, Cheng Lin, Xiaohui Hu, Yan Zhang, Bing Xiong, Xiushan Yin, Jinheng Fu, Wei He, Jingjing Duan and 6 more

Abstract readLetterComment
In one paragraph

Article in Science China. Life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. A SARS-CoV-2 MNature communications · 2025
    Article
  3. Article
  4. Crystal structures of the 3C proteases from Coxsackievirus B3 and B4.Acta crystallographica. Section F, Structural biology communications · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Crystal structure of SARS-CoV 3C-like protease with baicalein.Biochemical and biophysical research communications · 2022
    Article
  10. Crystal structures of human coronavirus NL63 main protease at different pH values.Acta crystallographica. Section F, Structural biology communications · 2021
    Article
  11. SARS-CoV-2 MBiomolecules · 2021
    Review
  12. Article
  13. Article
  14. The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2.Biochemical and biophysical research communications · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Xuelan Zhou *School of Basic Medical Sciences, Nanchang University, Nanchang, 330031, China.
Fanglin Zhong *College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, 341000, China.
Cheng LinShenzhen Crystalo Biopharmaceutical Co., Ltd, Shenzhen, 518118, China.
Xiaohui HuSchool of Basic Medical Sciences, Nanchang University, Nanchang, 330031, China.
Yan ZhangThe Second Affiliated Hospital of Nanchang University, Nanchang, 330031, China.
Bing XiongDepartment of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Xiushan YinApplied Biology Laboratory, Shenyang University of Chemical Technology, Shenyang, 110142, China.
Jinheng FuJiangxi-OAI Joint Research Institution, Nanchang University, Nanchang, 330047, China.
Wei HeCollege of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, 341000, China.
Jingjing DuanHuman Aging Research Institute (HARI), School of Life Sciences, Nanchang University, Nanchang, 330031, China.
Yang FuSchool of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China.
Huan ZhouShanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201204, China.
Peter J McCormickCentre for Endocrinology, William Harvey Research Institute, Bart's and the London School of Medicine and Dentistry, Queen Mary, University of London, London, EC1M 6BQ, UK.
Qisheng WangShanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201204, China. wangqisheng@zjlab.org.cn.
Jian LiCollege of Pharmaceutical Sciences, Gannan Medical University, Ganzhou, 341000, China. rmsl_2040@163.com.
Jin ZhangSchool of Basic Medical Sciences, Nanchang University, Nanchang, 330031, China. zhangxiaokong@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antiviral AgentsCOVID-19HumansPeptide HydrolasesSARS-CoV-2Viral Nonstructural ProteinsAntiviral AgentsPeptide HydrolasesViral Nonstructural Proteins

Identifiers

PMID32880863
PMCPMC7471536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.