ReviewPediatric nephrology (Berlin, Germany)2021
Prematurity, perinatal inflammatory stress, and the predisposition to develop chronic kidney disease beyond oligonephropathy.
Review in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Protecting Kidney Health in the First 1000 Days: The Pediatrician's Role in Safeguarding the Weakest.Diseases (Basel, Switzerland) · 2026Review
- Multifactorial chronic kidney disease and the kidney capacity-workload balance.Nature reviews. Nephrology · 2026Review
- Frequency and short-term persistence of haematuria and/or proteinuria in neonates: a cohort study.European journal of pediatrics · 2026Article
- Renal consequences of prematurity and utility of serum uromodulin as a marker of kidney growth- a cross sectional single centre study.BMC nephrology · 2026Article
- The Link Between Preterm Birth and Long-Term Renal Consequences: Current Knowledge and Emerging Therapeutic Targets.Biomedicines · 2026Review
- Preserving nephron number in children after preterm birth: a top priority.Pediatric nephrology (Berlin, Germany) · 2026Article
- Early Nutritional Patterns and Metabolic Biomarkers Associated with ROP Severity.Medicina (Kaunas, Lithuania) · 2026Article
- A novel mouse model for investigating the long-term impact of reduced nephron numbers on renal function and salt sensitivity.Pediatric research · 2025Article
- Birthweight and risk of chronic kidney disease after a type 2 diabetes diagnosis in the DD2 cohort.Diabetologia · 2025Article
- Radial Expansion of the Nephrogenic Zone in the Fetal Human Kidney During Advanced Pregnancy: A Microanatomical Look at a Little Noticed Process.International journal of nephrology · 2025Article
- The border between progenitor cell recruitment and nephron shaping in the fetal human kidney during late gestation: a basic but understudied region.Frontiers in nephrology · 2025Article
- Pharmacovigilance of nephrotoxic drugs in neonates: the Pottel method for acute kidney injury detection in ELBW neonates.Pediatric nephrology (Berlin, Germany) · 2024Article
- Installation of the developing nephron in the fetal human kidney during advanced pregnancy.Molecular and cellular pediatrics · 2023Article
- Diagnosis and management of mineral and bone disorders in infants with CKD: clinical practice points from the ESPN CKD-MBD and Dialysis working groups and the Pediatric Renal Nutrition Taskforce.Pediatric nephrology (Berlin, Germany) · 2023Review
- Environmental and parental risk factors for congenital solitary functioning kidney - a case-control study.Pediatric nephrology (Berlin, Germany) · 2023Article
- The impact of intrauterine growth restriction and prematurity on nephron endowment.Nature reviews. Nephrology · 2023Review
- The role of hepatic and renal functions in the development of retinopathy of prematurity: Is proteinuria a new risk factor?International ophthalmology · 2023Article
- Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders.Nutrients · 2022Review
- The interstitium at the developing nephron in the fetal kidney during advanced pregnancy - a microanatomical inventory.Molecular and cellular pediatrics · 2022Article
- Chorioamnionitis Causes Kidney Inflammation, Podocyte Damage, and Pro-fibrotic Changes in Fetal Lambs.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prematurity and perinatal stress, such as intrauterine growth restriction (IUGR) and chorioamnionitis, are pathological processes creating an impaired intrauterine environment. These intrauterine factors are associated with the development of proteinuria, hypertension, and chronic kidney disease (CKD) later in life. Initially, this was thought to be secondary to oligonephropathy, subsequent glomerular hypertrophy, and hyperfiltration, leading to glomerulosclerosis, a further decrease in nephron number, and finally CKD. Nowadays, there is increasing evidence that prematurity and perinatal stress affect not only nephron endowment but also the maturation of podocytes and vasculogenesis. IUGR is associated with podocyte damage and an aggravated course of nephrotic syndrome. Moreover, preterm birth and IUGR are known to cause upregulation of the postnatal renin-angiotensin system, resulting in hypertension. Chorioamnionitis causes damage to the glomeruli, thereby predisposing to the development of glomerulosclerosis. This review aims to summarize current knowledge on the influence of prematurity, IUGR, and chorioamnionitis on the development of different glomerular structures. After summarizing human and experimental data on low nephron number in general, a specific focus on the current understanding of podocyte and glomerular capillary formation in relation to prematurity and different causes of perinatal stress is presented.
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