Evidence map›Paper›PMID 32880676›Full record

SynthesisClinical research in cardiology : official journal of the German Cardiac Society2021

Prognostic impact of atrial fibrillation in hypertrophic cardiomyopathy: a systematic review.

Patricia Alphonse, Sohaib Virk, Jhonna Collins, Timothy Campbell, Stuart P Thomas, Christopher Semsarian, Saurabh Kumar

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical research in cardiology : official journal of the German Cardiac Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Guideline
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  6. Review
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  9. Article
  10. Hemodynamics in Left-Sided Cardiomyopathies.Reviews in cardiovascular medicine · 2024
    Review
  11. Understanding the incidence of atrial fibrillation and stroke in hypertrophic cardiomyopathy patients: insights from Danish nationwide registries.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  12. Article
  13. Review
  14. An Update on MYBPC3 Gene Mutation in Hypertrophic Cardiomyopathy.International journal of molecular sciences · 2023
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Patricia AlphonseDepartment of Cardiology, Westmead Hospital, Corner Hawkesbury and Darcy Roads, Westmead, Sydney, NSW, 2145, Australia.
Sohaib VirkDepartment of Cardiology, Westmead Hospital, Corner Hawkesbury and Darcy Roads, Westmead, Sydney, NSW, 2145, Australia.
Jhonna CollinsNepean Clinical School, University of Sydney, Sydney, Australia.
Timothy CampbellDepartment of Cardiology, Westmead Hospital, Corner Hawkesbury and Darcy Roads, Westmead, Sydney, NSW, 2145, Australia.
Stuart P ThomasDepartment of Cardiology, Westmead Hospital, Corner Hawkesbury and Darcy Roads, Westmead, Sydney, NSW, 2145, Australia.
Christopher SemsarianAgnes Ginges Centre for Molecular Cardiology at Centenary Institute, Department of Cardiology, The University of Sydney, Royal Prince Alfred Hospital, Sydney, Australia.
Saurabh KumarDepartment of Cardiology, Westmead Hospital, Corner Hawkesbury and Darcy Roads, Westmead, Sydney, NSW, 2145, Australia. Saurabh.kumar@sydney.edu.au.
Westmead Hospital · AUNepean Hospital · AURoyal Prince Alfred Hospital · AUThe University of Sydney · AUWestmead Institute · AU

Funding

Biosense Webster Speakers HonorariaNSW Health Early-Mid Career Fellowship
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is an important arrhythmia in hypertrophic cardiomyopathy (HCM).

objectivesTo conduct a systematic review of published literature to: (a) assess the incidence of AF in HCM and (b) examine the impact of AF on risk of thromboembolism, heart failure, sudden death and mortality in HCM.

methodsSearch of all major databases (Pubmed, MEDLINE, Embase, Cochrane, Scopus, Web of Science) was performed to April 2020 using the search terms "atrial fibrillation" AND/OR "hypertrophic cardiomyopathy" in the title or abstract. 51 of the 1,565 citations met the inclusion criteria.

resultsUsing random-effects modelling, the estimated pooled prevalence of AF amongst 21,887 HCM patients (36 studies) was 22.3% (95%, 19.9-24.8) and the pooled incidence of AF was 2.5 cases per person-years (95% CI 1.9-3.0). 15,444 patients from 28 studies were included in analysis of outcome data (mean age was 49.9 years; 32.7% female; mean LVEF 69%). Over a median follow up duration of 6.9 years (range 2.8-11.7 years), AF, compared to sinus rhythm (SR), was associated with significantly increased risk of thromboembolism [relative risk (RR) 7.0; 95% CI 4.6-10.7; I

conclusionsAF is highly prevalent in patients with HCM. The presence of AF is associated with major adverse clinical outcomes. These findings suggest that both, aggressive screening and treatment of AF, are likely to have major prognostic impact on outcomes in HCM. Incidence, prevalence and prognostic impact of AF in HCM. In this systematic review, AF incidence was 2.5 cases per-person years, prevalence was 22.3%. AF in HCM was associated with a seven-fold increased risk of thromboembolism, 2.8-fold increased risk of heart failure, 1.7-fold increased risk of sudden death and 2.5-fold increased risk of all-cause mortality.

Indexed as

Risk AssessmentAtrial FibrillationCardiomyopathy, HypertrophicGlobal HealthHumansIncidenceThromboembolismAtrial fibrillationHeart failureHypertrophic cardiomyopathyMorbidityMortalitySudden deathThromboembolism

Identifiers

PMID32880676
OpenAlexW3083746933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.