Evidence map›Paper›PMID 32880628›Full record

ArticleThe Journal of infectious diseases2022

Exportation of Monkeypox Virus From the African Continent.

Matthew R Mauldin, Andrea M McCollum, Yoshinori J Nakazawa, Anna Mandra, Erin R Whitehouse, Whitni Davidson, Hui Zhao, Jinxin Gao, Yu Li, Jeffrey Doty and 30 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. How can imported monkeypox break the borders? A rapid systematic review.Comparative immunology, microbiology and infectious diseases · 2023
    Pooled it
  7. Trial
  8. Article
  9. Six Cases of Borealpox and Evidence of a Zoonotic Source: Alaska, 2020-2023.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
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  13. Article
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  15. Article
  16. Article
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  19. From neglected to notoriety: a review of Mpox clinical features, virology, epidemiology, treatment and prevention strategies.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Review
  20. Review

126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Matthew R MauldinPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0002-3807-2339
Andrea M McCollumPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Yoshinori J NakazawaPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Anna MandraPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Erin R WhitehousePoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Whitni DavidsonPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Hui ZhaoPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jinxin GaoPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Yu LiPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jeffrey DotyPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Adesola Yinka-OgunleyeNigerian Centre for Disease Control, Abuja, Nigeria.
Afolabi AkinpeluNigerian Centre for Disease Control, Abuja, Nigeria.
Olusola ArunaInternational Health Regulations Strengthening Project, Global Public Health, Public Health England, London, United Kingdom.
Dhamari NaidooWorld Health Organization Country Office, Abuja, Nigeria.
Kuiama LewandowskiPublic Health England, London, United Kingdom.
Babak AfroughPublic Health England, London, United Kingdom.
Victoria GrahamPublic Health England, London, United Kingdom.
Emma AaronsPublic Health England, London, United Kingdom.
Roger HewsonPublic Health England, London, United Kingdom.
Richard VipondPublic Health England, London, United Kingdom.
Jake DunningPublic Health England, London, United Kingdom.
Meera ChandPublic Health England, London, United Kingdom.
Colin BrownPublic Health England, London, United Kingdom.
Inbar Cohen-GihonDepartment of Biochemistry and Molecular Biology, Israel Institute for Biological Research, Ness-Ziona, Israel.
Noam ErezDepartment of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel.
Ohad ShifmanDepartment of Biochemistry and Molecular Biology, Israel Institute for Biological Research, Ness-Ziona, Israel.
Ofir IsraeliDepartment of Biochemistry and Molecular Biology, Israel Institute for Biological Research, Ness-Ziona, Israel.
Melamed SharonDepartment of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel.
Eli SchwartzInstitute of Tropical Medicine, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Adi Beth-DinDepartment of Biochemistry and Molecular Biology, Israel Institute for Biological Research, Ness-Ziona, Israel.
Anat ZviDepartment of Biochemistry and Molecular Biology, Israel Institute for Biological Research, Ness-Ziona, Israel.
Tze Minn MakNational Public Health Laboratory, National Centre for Infectious Diseases, Singapore.
Yi Kai NgNational Public Health Laboratory, National Centre for Infectious Diseases, Singapore.
Lin CuiNational Public Health Laboratory, National Centre for Infectious Diseases, Singapore.
Raymond T P LinNational Public Health Laboratory, National Centre for Infectious Diseases, Singapore.
Victoria A OlsonPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Tim BrooksPublic Health England, London, United Kingdom.
Nir ParanDepartment of Infectious Diseases, Israel Institute for Biological Research, Ness-Ziona, Israel.
Chikwe IhekweazuNigerian Centre for Disease Control, Abuja, Nigeria.
Mary G ReynoldsPoxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Funding

CDC's Global Disease Detection ProgramWorld Health Organization 001
6 · The paper itself

Abstract

backgroundThe largest West African monkeypox outbreak began September 2017, in Nigeria. Four individuals traveling from Nigeria to the United Kingdom (n = 2), Israel (n = 1), and Singapore (n = 1) became the first human monkeypox cases exported from Africa, and a related nosocomial transmission event in the United Kingdom became the first confirmed human-to-human monkeypox transmission event outside of Africa.

methodsEpidemiological and molecular data for exported and Nigerian cases were analyzed jointly to better understand the exportations in the temporal and geographic context of the outbreak.

resultsIsolates from all travelers and a Bayelsa case shared a most recent common ancestor and traveled to Bayelsa, Delta, or Rivers states. Genetic variation for this cluster was lower than would be expected from a random sampling of genomes from this outbreak, but data did not support direct links between travelers.

conclusionsMonophyly of exportation cases and the Bayelsa sample, along with the intermediate levels of genetic variation, suggest a small pool of related isolates is the likely source for the exported infections. This may be the result of the level of genetic variation present in monkeypox isolates circulating within the contiguous region of Bayelsa, Delta, and Rivers states, or another more restricted, yet unidentified source pool.

Indexed as

Monkeypox virusMpox, MonkeypoxDisease OutbreaksHumansNigeriaUnited Kingdomborder healthexportationhaplotype networksmonkeypox virustravel epidemiologyviral genomes

Identifiers

PMID32880628
PMCPMC9016419

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.