ArticleAmerican journal of clinical pathology2020
Molecular and Immunohistochemical Analysis of Mucinous Cystic Neoplasm of the Liver.
Article in American journal of clinical pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Benign Biliary Tumors and Precursor Neoplasms: An Updated Clinicopathological and Molecular Review Based on the 2026 WHO Classification.Biomedicines · 2026Review
- A nomogram‑based diagnostic prediction model for differentiating mucinous cystic neoplasms from simple hepatic cysts in patients with hepatic cystic lesions.Journal of gastrointestinal oncology · 2026Article
- Mucinous cystic neoplasms of the liver: current insights into epidemiology, diagnosis, and treatment.Frontiers in surgery · 2026Review
- Hepatic mucinous cystic neoplasm in a male patient: A case report.Experimental and therapeutic medicine · 2025Article
- Mucinous cystic neoplasms of the liver: Literature review and case series.World journal of clinical oncology · 2025Review
- Refining imaging criteria for mucinous cystic neoplasm of the liver: simplified diagnostic approach.European radiology · 2025Article
- Obstructive Jaundice Induced by Hilar Mucinous Cystic Neoplasm of the Liver: A Rare Case Report and Literature Review.Current oncology (Toronto, Ont.) · 2025Review
- Mucinous cystic neoplasms of the pancreas demonstrateFrontiers in cell and developmental biology · 2025Article
- Morphological aspects of small-duct cholangiopathies: A minireview.World journal of hepatology · 2023Review
- Risk Assessment and Cholangiocarcinoma: Diagnostic Management and Artificial Intelligence.Biology · 2023Review
- Mucinous Cystic Neoplasms of the Liver: Epidemiology, Diagnosis, and Management.Hepatic medicine : evidence and research · 2023Review
- Pathological, molecular, and clinical characteristics of cholangiocarcinoma: A comprehensive review.World journal of gastrointestinal oncology · 2022Review
- Intralobular distribution of ovarian-like stroma in pancreatic mucinous cystic neoplasms: a discussion on its tumorigenesis.Scientific reports · 2022Article
- Mucinous cystic neoplasm of the liver: A case report.World journal of clinical cases · 2021Article
- Mucin-producing Cystic Hepatobiliary Neoplasms: Updated Nomenclature and Clinical, Pathologic, and Imaging Features.Radiographics : a review publication of the Radiological Society of North America, Inc · 2021Article
- Mucinous Cystic Adenoma of the Liver: A Thought-Provoking Case of an Uncommon Hepatic Neoplasm.The American journal of case reports · 2021Article
- Complex cystic liver lesions: classification, diagnosis, and management.Annals of gastroenterologyReview
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 2 countries.
Funding
Abstract
objectivesMucinous cystic neoplasm of the liver is characterized by neoplastic mucinous and/or biliary epithelium surrounded by ovarian-type stroma. Immunohistochemical studies have shown that the ovarian-type stroma expresses estrogen receptor, suggesting potential hormonal responsiveness. The molecular biology of mucinous cystic neoplasm of the liver remains poorly studied.
methodsTranscriptome sequencing and immunohistochemistry were performed on a series of mucinous cystic neoplasms.
resultsMucinous cystic neoplasm of the liver exhibited significantly increased RNA expression of ovarian stromal markers WT1, PR, and ER2 and sex cord stromal markers SF-1, inhibin-α, and calretinin compared with nonneoplastic liver. Immunohistochemistry confirmed the RNA-level data. Evidence for sex hormone biosynthesis was identified by significant overexpression of multiple estrogen biosynthetic enzymes. Expression of 17β-hydroxysteroid dehydrogenase 1 was confirmed immunohistochemically. Pathway analysis also identified significant upregulation of the hedgehog and Wnt pathways and significant downregulation of T-helper 1 and T-helper 2 pathways.
conclusionsMucinous cystic neoplasm of the liver recapitulates ovarian stroma at the morphologic, DNA, RNA, and protein levels. These data support the concept that this tumor likely arises from ectopic primitive gonadal tissue and/or stromal cells with capacity to transdifferentiate to ovarian cortical cells.
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