Evidence map›Paper›PMID 32880102›Full record

ArticleInfectious diseases and therapy2020

Efficacy Evaluation of Early, Low-Dose, Short-Term Corticosteroids in Adults Hospitalized with Non-Severe COVID-19 Pneumonia: A Retrospective Cohort Study.

Qiang Li, Weixia Li, Yinpeng Jin, Wei Xu, Chenlu Huang, Li Li, Yuxian Huang, Qingchun Fu, Liang Chen

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In one paragraph

Article in Infectious diseases and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  18. Perioperative use of intra-articular steroids during the COVID-19 pandemic.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qiang Li *Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Weixia Li *Department of Infectious Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yinpeng Jin *Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Wei Xu *Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Chenlu Huang *Department of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Li LiDepartment of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yuxian HuangDepartment of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Qingchun FuDepartment of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. fuqingchun@shphc.org.cn.
Liang ChenDepartment of Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. chenliang@shphc.org.cn.

Funding

Shanghai Sailing Plan Program 19YF1441200Shanghai Science and Technology Development Foundation 17411969700
6 · The paper itself

Abstract

objectivesThis study aimed to observe the efficacy of corticosteroids in non-severe COVID-19 pneumonia.

methodsA retrospective study based on propensity score matching was designed to explore the effects of corticosteroids. Primary outcomes included the rate of patients who developed severe disease and mortality. Secondary outcomes included duration of fever, virus clearance time, length of hospital stay, and the use of antibiotics.

resultsA total of 475 patients with non-severe COVID-19 pneumonia were enrolled, 55 patients received early, low-dose, and short-term corticosteroids therapy, 420 patients received non-corticosteroids therapy. Compared to the non-corticosteroids group, there was a prolonged duration of fever (median 5 vs 3 days, p < 0.001), virus clearance time (median 18 vs 11 days, p < 0.001), and length of hospital stay (median 23 vs 15 days, p < 0.001) in the corticosteroids group. The percentages of antibiotics therapy (89.1% vs 23.6%, p < 0.001), use of at least two antibiotics (38.2% vs 12.7%, p = 0.002), and antifungal therapy (7.3% vs 0, p = 0.042) were higher in the corticosteroids group than those in the non-corticosteroids group. Compared to the non-corticosteroids group, more patients developed severe disease (12.7% vs 1.8%, p = 0.028) in the corticosteroids group. There was no significant difference between the two groups in mortality (1.8% vs 0, p = 0.315).

conclusionIn adult patients with non-severe COVID-19 pneumonia, early, low-dose, and short-term corticosteroids therapy was associated with worse clinical outcomes.

Indexed as

2019 novel coronavirus diseaseCorticosteroidsEfficacy evaluationNon-severe COVID-19 infectionsSevere acute respiratory syndrome coronavirus 2

Identifiers

PMID32880102
PMCPMC7467137

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.