Evidence map›Paper›PMID 32880091›Full record

ArticleInternational urology and nephrology2021

Immediate preoperative renal artery embolization in the resection of complex renal tumors (UroCCR-48 Reinbol study).

C Alegorides, P Bigot, J Hardwigsen, V Vidal, A Riberi, M Andre, B Gondran-Tellier, M Baboudjian, F Michel, G Karsenty and 3 more

Registry-linked trialAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03293563 (UroCCR Database), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03293563 recruitingnot on this map

UroCCR Database: French Research Network for Kidney Cancer (National Multidisciplinary Clinical and Biological Database on Kidney Cancer)

TypeobservationalSponsorUniversity Hospital, BordeauxRan2011 to 2040Enrolled30,000ConditionsKidney CancerArmsRadical nephrectomy versus partial nephrectomy (according surgeon judgement)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

C AlegoridesDepartment of Urology and Kidney Transplantation, Aix-Marseille University, APHM, Conception University Hospital, Marseille, France.
P BigotDepartment of Urology, University of Angers, Angers, France.
J HardwigsenDepartment of Liver Transplantation, Aix-Marseille University, APHM, La Timone University Hospital, Marseille, France.
V VidalDepartment of Radiology, Aix-Marseille University, APHM, La Timone University Hospital, Marseille, France.
A RiberiDepartment of Cardiac Surgery, Aix-Marseille University, APHM, La Timone University Hospital, Marseille, France.
M AndreDepartment of Radiology, La Conception University Hospital, Marseille, France.
B Gondran-TellierDepartment of Urology and Kidney Transplantation, Aix-Marseille University, APHM, Conception University Hospital, Marseille, France.
M BaboudjianDepartment of Urology and Kidney Transplantation, Aix-Marseille University, APHM, Conception University Hospital, Marseille, France.
F MichelDepartment of Urology and Kidney Transplantation, Aix-Marseille University, APHM, Conception University Hospital, Marseille, France.
G KarsentyDepartment of Urology and Kidney Transplantation, Aix-Marseille University, APHM, Conception University Hospital, Marseille, France.
E LechevallierDepartment of Urology and Kidney Transplantation, Aix-Marseille University, APHM, Conception University Hospital, Marseille, France.
J C BernhardDepartment of Urology, University of Bordeaux, Bordeaux, France.
R BoissierDepartment of Urology and Kidney Transplantation, Aix-Marseille University, APHM, Conception University Hospital, Marseille, France. Romain.Boissier@ap-hm.fr.
Aix-Marseille Université · FRHôpital de la Conception · FRUniversité d'Angers · FRUniversité de Bordeaux · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe evaluated the feasibility and outcomes of immediate preoperative renal artery embolization (IPRAE) before complex nephrectomy for locally advanced RCC ± inferior vena cava thrombus (IVCT).

methodsA comparative retrospective (2007-2017) multicenter study which included 145 patients with locally advanced RCC ± IVCT: 99 radical nephrectomies vs. 46 radical nephrectomies with IPRAE identified in the prospective UroCCR national database (CNIL DR 2013-206; NCT03293563). IPRAE was performed under local anesthesia the day of nephrectomy (< 4 h prior to nephrectomy). The primary endpoint was peroperative blood loss (mL). Secondary outcomes were: tolerance of embolization (pain visual scale), success rate of IPRAE defined by complete devascularization of the kidney, perioperative complications according to Clavien score and postoperative GFR.

resultsThe baseline characteristics of IPRAE and the control groups were similar. Tumor staging was 14% T2b, 41% T3a, 27% T3b, 13% T3c, 6% T4. The success rate of IPRAE was 98%. Median artery embolizated per patient was 2 (Agochukwu and Shuch in World J Urol 32:581-589, 2014; Marshall et al. in J Urol 139:1166-1172, 1988; Yap et al. in BJU Int 110:1283-1288, 2012;Gill et al. in J Urol. 194:929-938, 2015; Wang et al. in Eur Urol 69:1112-1119, 2016). No severe complications occurred after IPRAE. Postembolization syndrome was reported in 7% (Clavien I-II). Mean peroperative blood losses in the IPRAE and control groups were: 726 ± 118 ml and 1083 ± 114 ml (P = 0.03). In a multivariate analysis that included: age, Karnofsky index, IPRAE (yes vs. no), IVCT (yes vs. no), tumor size and synchronous metastasis, no IPRAE and IVCT were significantly associated with increased peroperative bleeding.

conclusionIPRAE before nephrectomy for locally advanced and/or IVCT tumors was well tolerated, was associated with lower peroperative bleeding and did not increase the incidence or severity of postoperative complications.

Indexed as

Embolization, TherapeuticNephrectomyPreoperative CareRenal ArteryAgedCarcinoma, Renal CellFeasibility StudiesFemaleHumansKidney NeoplasmsMaleMiddle AgedNeoplasm StagingRetrospective StudiesTime FactorsTreatment OutcomeInferior vena cava thrombusLocally-advanced renal cell carcinomaRenal cell carcinomaRenal embolization

Identifiers

PMID32880091
OpenAlexW3081696991

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.