Evidence map›Paper›PMID 32880057›Full record

Trial reportEuropean archives of psychiatry and clinical neuroscience2021

Prefrontal resting-state connectivity and antidepressant response: no associations in the ELECT-TDCS trial.

Lucia Bulubas, Frank Padberg, Eva Mezger, Paulo Suen, Priscila V Bueno, Fabio Duran, Geraldo Busatto, Edson Amaro, Isabela M Benseñor, Paulo A Lotufo and 4 more

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European archives of psychiatry and clinical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. White matter predicts tDCS antidepressant effects in a sham-controlled clinical trial study.European archives of psychiatry and clinical neuroscience · 2023
    Trial
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Lucia BulubasDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Frank PadbergDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Eva MezgerDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Paulo SuenService of Interdisciplinary Neuromodulation, Department of Psychiatry, Laboratory of Neurosciences (LIM-27) and National Institute of Biomarkers in Neuropsychiatry (INBioN), Institute of Psychiatry, University of Sao Paulo, Instituto de Psiquiatria, Hospital das Clínicas, FMUSP, R. Dr. Ovidio Pires de Campos 785, 2o andar, Sao Paulo, 05403-903, Brazil.
Priscila V BuenoService of Interdisciplinary Neuromodulation, Department of Psychiatry, Laboratory of Neurosciences (LIM-27) and National Institute of Biomarkers in Neuropsychiatry (INBioN), Institute of Psychiatry, University of Sao Paulo, Instituto de Psiquiatria, Hospital das Clínicas, FMUSP, R. Dr. Ovidio Pires de Campos 785, 2o andar, Sao Paulo, 05403-903, Brazil.
Fabio DuranCenter for Interdisciplinary Research On Applied Neurosciences (NAPNA) and Laboratory of Psychiatric Neuroimaging, Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil.
Geraldo BusattoCenter for Interdisciplinary Research On Applied Neurosciences (NAPNA) and Laboratory of Psychiatric Neuroimaging, Department and Institute of Psychiatry, University of Sao Paulo, Sao Paulo, Brazil.
Edson AmaroDepartment of Radiology, Clinics Hospital, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Isabela M BenseñorDepartamento de Clínica Médica, Faculdade de Medicina da USP, Hospital Universitario, São Paulo, Brazil.
Paulo A LotufoDepartamento de Clínica Médica, Faculdade de Medicina da USP, Hospital Universitario, São Paulo, Brazil.
Stephan GoerigkDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Wagner GattazService of Interdisciplinary Neuromodulation, Department of Psychiatry, Laboratory of Neurosciences (LIM-27) and National Institute of Biomarkers in Neuropsychiatry (INBioN), Institute of Psychiatry, University of Sao Paulo, Instituto de Psiquiatria, Hospital das Clínicas, FMUSP, R. Dr. Ovidio Pires de Campos 785, 2o andar, Sao Paulo, 05403-903, Brazil.
Daniel Keeser *Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Andre R BrunoniDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany. brunowsky@gmail.com.
Universidade de São Paulo · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRLMU Klinikum · DEBrazilian Institute of Neuroscience and Neurotechnology · BRHochschule Fresenius · DELudwig-Maximilians-Universität München · DE

Funding

BMBF 01EE1403EFAPESP 2012/20911-5
6 · The paper itself

Abstract

Functional and structural MRI of prefrontal cortex (PFC) may provide putative biomarkers for predicting the treatment response to transcranial direct current stimulation (tDCS) in depression. A recent MRI study from ELECT-TDCS (Escitalopram versus Electrical Direct-Current Theror Depression Study) showed that depression improvement after tDCS was associated with gray matter volumes of PFC subregions. Based thereon, we investigated whether antidepressant effects of tDCS are similarly associated with baseline resting-state functional connectivity (rsFC). A subgroup of 51 patients underwent baseline rsFC-MRI. All patients of ELECT-TDCS were randomized to three treatment arms for 10 weeks (anodal-left, cathodal-right PFC tDCS plus placebo medication; escitalopram 10 mg/day for 3 weeks and 20 mg/day thereafter plus sham tDCS; and placebo medication plus sham tDCS). RsFC was calculated for various PFC regions and analyzed in relation to the individual antidepressant response. There was no significant association between baseline PFC connectivity of essential structural regions, nor any other PFC regions (after correction for multiple comparisons) and patients' individual antidepressant response. This study did not reveal an association between antidepressants effects of tDCS and baseline rsFC, unlike the gray matter volume findings. Thus, the antidepressant effects of tDCS may be differentially related to structural and functional MRI measurements.

Indexed as

RestTranscranial Direct Current StimulationAdultAntidepressive AgentsDepressionDouble-Blind MethodEscitalopramFemaleGray MatterHumansMajor Depressive DisorderMalePrefrontal CortexTreatment OutcomeAntidepressive AgentsEscitalopramAntidepressant responseMajor depressive disorder (MDD)Non-invasive transcranial brain stimulation (NTBS)Prefrontal cortexResting state functional connectivity (rsFC-MRI)Transcranial direct current stimulation (tDCS)

Identifiers

PMID32880057
OpenAlexW3082666523

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.