Evidence map›Paper›PMID 32879799›Full record

ArticlePeerJ2020

Genetic variations in the drug metabolizing enzyme, CYP2E1, among various ethnic populations of Pakistan.

Sagheer Ahmed, Nadeem Altaf, Mahnoor Ejaz, Zaira Zulfiqar, Kholood Janjua, Dana Festila, Nicula Cristina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sagheer AhmedPharmacogenetic Laboratory, Department of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
Nadeem AltafOverseas Pakistanis Foundation Boys College, Sector H-8, Islamabad, Pakistan.ORCID 0000-0002-8197-6923
Mahnoor EjazPharmacogenetic Laboratory, Department of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
Zaira ZulfiqarPharmacogenetic Laboratory, Department of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan.ORCID 0000-0001-7972-1641
Kholood JanjuaShifa Clinical Research Center, Shifa International Hospital, Islamabad, Pakistan.
Dana FestilaUniversity of Medicine and Pharmacy of Cluj-Napoca, Cluj-Napoca, Romania.
Nicula CristinaUniversity of Medicine and Pharmacy of Cluj-Napoca, Cluj-Napoca, Romania.ORCID 0000-0002-3222-6448
Shifa Tameer-e-Millat University · PKUniversity of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca · ROShifa International Hospital · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic polymorphism in cytochrome P450 (CYP) monooxygenase genes is an important source of interindividual variability of drug response. CYP enzyme activities may change as a result of such polymorphisms which then, may affect drug metabolism. This would result in a change in the severity and frequency of adverse effects in addition to the non-responder phenomenon. CYP2E1, a member of CYP superfamily, affects the metabolism of several clinically important drugs such as halothane, paracetamol, etc. Genetic variation in

Indexed as

CYP2E1Cytochrome P450PakistanPharmacogenomics

Identifiers

PMID32879799
PMCPMC7443092
OpenAlexW3077176571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.