ArticleNature2020
Cancer SLC43A2 alters T cell methionine metabolism and histone methylation.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 405 papers.
0numbers the graph read from it
0cells of the map it votes in
405citing papers in PubMed
22.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
405 citing papers in PubMed, 589 citations in OpenAlex.
- Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights.Genes & diseases · 2027Review
- Methionine Regulates Antitumour Function of CD8Immunology · 2026Article
- Metabolites and cancer metastasis.Oncogene · 2026Review
- The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Tumor-driven arginine depletion induces T-cell metabolism reprogramming to suppress atherosclerosis in colorectal cancer.Acta pharmacologica Sinica · 2026Article
- Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer.Signal transduction and targeted therapy · 2026Review
- Metabolic Bottlenecks and Opportunities: Reshaping the Tumor Microenvironment for Cancer Immunotherapy.Cells · 2026Review
- Metabolic-epigenetic crosstalk in innate immune cell plasticity within the tumor microenvironment.Experimental & molecular medicine · 2026Review
- Review
- Endogenous metabolite signaling orchestrates tumor immune evasion.Cell insight · 2026Review
- CXCR2-mediated metabolic interaction between prostate cancer cells and the immunosuppressive tumor microenvironment.Journal for immunotherapy of cancer · 2026Article
- Targeting DOT1L Reactivates HERV-K to Drive Cell-Autonomous and Paracrine Senescence in Adenocarcinoma of the Esophagogastric Junction.Cancer research · 2026Article
- Plasma trimethylamine N-oxide and related metabolites and overall survival of high-grade serous ovarian cancer: a nested case-control study.European journal of nutrition · 2026Article
- Role of methionine metabolism in cancer: recent advances in molecular mechanisms and therapeutic implications.Experimental hematology & oncology · 2026Review
- Emerging roles of ferroptosis in modulating the immune landscape of glial tumours.Nature cell biology · 2026Review
- The competition of amino acid among tumors, tumor-associated macrophages and T cells based on metabolic reprogramming.iScience · 2026Review
- Review
- Article
- Smart responsive hydrogels combined with AI design for tumor therapy.Acta pharmaceutica Sinica. B · 2026Review
- Amino Acids as Targets for Immunotherapy against Solid Tumors.Cell biochemistry and biophysics · 2026Review
345 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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- Erratum issued
Authors and funding
29 authors at 4 institutions in 2 countries.
Yingjie Bian *Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9599-9907
Wei Li *Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Daniel M KremerDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-6224-0550
Peter SajjakulnukitDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8556-7481
Shasha LiDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Joel CrespoDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Zeribe C NwosuDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1641-2045
Li ZhangDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Arkadiusz CzerwonkaDepartment of Virology and Immunology, Maria Curie-Skłodowska University, Lublin, Poland.
Anna PawłowskaFirst Chair and Department of Oncological Gynecology and Gynecology, Medical University of Lublin, Lublin, Poland.ORCID http://orcid.org/0000-0003-1532-2662
Houjun XiaDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Jing LiDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Peng LiaoDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8409-5574
Jiali YuDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Linda VatanDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Wojciech SzeligaDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Shuang WeiDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.
Sara GroveDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.
J Rebecca LiuDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Karen McLeanDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Marcin CieslikDepartment of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Arul M ChinnaiyanDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-8743-7480
Witold ZgodzińskiSecond Department of General, Gastrointestinal Surgery and Surgical Oncology of the Alimentary Tract, Medical University of Lublin, Lublin, Poland.ORCID http://orcid.org/0000-0003-3838-5789
Grzegorz WallnerSecond Department of General, Gastrointestinal Surgery and Surgical Oncology of the Alimentary Tract, Medical University of Lublin, Lublin, Poland.
Iwona WertelFirst Chair and Department of Oncological Gynecology and Gynecology, Medical University of Lublin, Lublin, Poland.
Karolina OkłaFirst Chair and Department of Oncological Gynecology and Gynecology, Medical University of Lublin, Lublin, Poland.
Ilona KryczekDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3130-2533
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-9309-6141
Weiping ZouDepartment of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA. wzou@med.umich.edu.ORCID http://orcid.org/0000-0001-7952-3549
University of Michigan · USMedical University of Lublin · PLHoward Hughes Medical Institute · USMaria Curie-Skłodowska University · PL
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2MStatistics and Bioinformatics Core - WangU24DK097153 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURANT, CHARLES F · 2012 to 2017
$10.1MTraining Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3MNaive T cells in Cancer Immune Evasion and ImmunotherapyR01CA217510 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2017 to 2021
$3.3MMetabolic impact on T cell-mediated cancer immunity and therapyR01CA248430 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2020 to 2024
$3.2MOvarian Cancer Epigenetics, Immunity and TherapyR01CA214911 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2018 to 2022
$3.1MImmune Impact on Cancer ChemoresistanceR01CA211016 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2017 to 2021
$3.0MEffector T Cell Trafficking in Ovarian CancerR01CA190176 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2015 to 2019
$2.6MIntratumoral Metabolic Crosstalk Promotes Therapeutic Resistance in Pancreatic CancerR37CA237421 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Costas Andreas Lyssiotis · 2020 to 2026
$2.6MMDSCs in Ovarian CancerR01CA193136 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2015 to 2019
$2.5MMemory T Cells in the Tumor MicroenvironmentR01CA152470 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2011 to 2015
$1.9MHuman Tregs in Ovarian CancerR01CA099985 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZOU, WEIPING · 2006 to 2014
$1.8MNCI NIH HHS CA099985NCI NIH HHS CA123088NCI NIH HHS CA152470NCI NIH HHS CA193136NCI NIH HHS CA217648NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA099985NCI NIH HHS R01 CA123088NCI NIH HHS R01 CA152470NCI NIH HHS R01 CA190176NCI NIH HHS R01 CA193136NCI NIH HHS R01 CA211016NCI NIH HHS R01 CA214911NCI NIH HHS R01 CA217510NCI NIH HHS R01 CA248430NCI NIH HHS R37 CA237421NCI NIH HHS T32 CA009676NIDDK NIH HHS U24 DK097153NIH HHS DK097153
Abstract
Abnormal epigenetic patterns correlate with effector T cell malfunction in tumours
Indexed as
MethylationAmino Acid Transport System LAnimalsCD8-Positive T-LymphocytesCell Line, TumorEpigenesis, GeneticFemaleHistonesHumansMethionineMiceNeoplasmsReceptors, Antigen, T-CellSTAT5 Transcription FactorAmino Acid Transport System LHistonesMethionineReceptors, Antigen, T-CellSlc43a2 protein, mouseSTAT5 Transcription Factor
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.