ArticleNature2020
Shared structural mechanisms of general anaesthetics and benzodiazepines.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 199 papers.
0numbers the graph read from it
0cells of the map it votes in
199citing papers in PubMed
19.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
199 citing papers in PubMed, 372 citations in OpenAlex.
- Seizure adequacy and safety of remimazolam in electroconvulsive therapy for patients with psychiatric disorders: a double-blind randomized crossover trial.BMC psychiatry · 2026Trial
- NH600001, an etomidate analogue, provides gastrointestinal endoscopy sedation/anesthesia and reduces adrenocortical depression: two randomized controlled trials.Nature communications · 2026Trial
- Effects of Remimazolam-Propofol with Flumazenil Reversal on the Emergence Time and Hemodynamics of Patients Undergoing Laparoscopic Partial Hepatectomy: A Prospective Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- The Effect of Different Doses of Ciprofol in Patients with Painless Gastrointestinal Endoscopy.Drug design, development and therapy · 2023Trial
- Alchemical Free Energy Perturbation Predicts Relative Binding Affinities of Propofol Analogs and Etomidate Stereoisomers at the GABAACS omega · 2026Article
- In vivo and In Silico Assessment of Acampe papillosa (Lindl.) Lindl. Seed Extract: A Multi-Pharmacological Approach.Cell biochemistry and biophysics · 2026Article
- Molecular arrangement and modulation of extrasynaptic αβδ GABANature communications · 2026Article
- General anesthetic modulation of a pentameric ligand-gated ion channel explored with simulations.Biophysical journal · 2026Article
- Determining the molecular and physiological actions of subtype-selective nanobodies of GABAScience advances · 2026Article
- Thiazol-4-yl-Methylthio-Quinazolin-4(3H)-ones as Anticonvulsant Compounds: Chemical Design, Computational Studies, and Biological Evaluation.International journal of molecular sciences · 2026Article
- Effects of ivermectin on the activation and desensitization of the human GABAMolecular pharmacology · 2026Article
- The serotonin-gated 5-HT3 receptor: a tale of functions and structures of a prototypical pentameric ligand-gated ion channel.Acta pharmacologica Sinica · 2026Review
- Structural basis for activation and potentiation in a human α5β3 GABANature communications · 2026Article
- GABACellular and molecular neurobiology · 2026Review
- Molecular Mechanisms and Probe-Dependent Effects of Clinically Relevant GABAArchiv der Pharmazie · 2026Article
- An atomic interaction conserved for over 600 million years gates inhibitory neurotransmission.bioRxiv : the preprint server for biology · 2026Article
- Human GlyRα2 pore dynamics in gating and inhibition.Structure (London, England : 1993) · 2026Article
- Phytochemical Characterization and Neuropharmacological Assessment ofFood science & nutrition · 2026Article
- In vitro γ-aminobutyric acid A (GABACommunications chemistry · 2026Article
- From target specificity to metabolic efficiency: Design and optimization of etomidate analogues for potential improvement in postoperative outcomes.Acta pharmaceutica Sinica. B · 2026Article
139 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Jeong Joo KimDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Anant GharpureDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jinfeng TengDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Yuxuan ZhuangDepartment of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden.ORCID http://orcid.org/0000-0003-4390-8556
Rebecca J HowardDepartment of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden.ORCID http://orcid.org/0000-0003-2049-3378
Shaotong ZhuDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Colleen M NovielloDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Richard M WalshDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8939-8988
Erik LindahlDepartment of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, Solna, Sweden.
Ryan E HibbsDepartment of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA. ryan.hibbs@utsouthwestern.edu.ORCID http://orcid.org/0000-0003-4283-1147
The University of Texas Southwestern Medical Center · USStockholm University · SEHarvard University · USSouthwestern Medical Center · US
Funding
Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8MStructure and Function of GABA-A ReceptorsR01DA047325 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI Ryan E Hibbs, David W Nauen · 2019 to 2026
$4.4MStructural studies of heteromeric nicotinic acetylcholine receptors - Diversity SupplementR01DA042072 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI HIBBS, RYAN E · 2016 to 2020
$2.0M3D Structure and mechanism of the alpha7 nicotinic acetylcholine receptorR01NS095899 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI HIBBS, RYAN E · 2016 to 2020
$1.8MStructural biology of the alpha4beta2 nicotinic acetylcholine receptorR33DA037492 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI HIBBS, RYAN E · 2017 to 2018
$802kStructural biology of the alpha4beta2 nicotinic acetylcholine receptorR21DA037492 · NIDA · UT SOUTHWESTERN MEDICAL CENTER · PI HIBBS, RYAN E · 2014 to 2015
$368kAmerican Heart Association-American Stroke AssociationNIDA NIH HHS R01 DA042072NIDA NIH HHS R01 DA047325NIDA NIH HHS R21 DA037492NIDA NIH HHS R33 DA037492NIGMS NIH HHS U24 GM129547NIH HHS DA037492NINDS NIH HHS R01 NS095899
Abstract
Most general anaesthetics and classical benzodiazepine drugs act through positive modulation of γ-aminobutyric acid type A (GABA
Indexed as
Cryoelectron MicroscopyAllosteric RegulationAnesthetics, GeneralBarbituratesBenzodiazepinesBicucullineBinding, CompetitiveBinding SitesDiazepamElectrophysiologyEtomidateFlumazenilGABA-A Receptor Antagonistsgamma-Aminobutyric AcidHumansLigandsAnesthetics, GeneralBarbituratesBenzodiazepinesBicucullineDiazepamEtomidateFlumazenilGABA-A Receptor Antagonistsgamma-Aminobutyric AcidLigandsPhenobarbitalPicrotoxinPropofolReceptors, GABA-A
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.