ArticleNature2020
The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
235citing papers in PubMed, 3 pooled it
23.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
235 citing papers in PubMed, 3 syntheses or guidelines pooled it, 373 citations in OpenAlex.
- Rethinking Alzheimer's: novel miRNAs illuminate a disease beyond the brain.Molecular psychiatry · 2026Pooled it
- Unveiling sex-based differences in Parkinson's disease: a comprehensive meta-analysis of transcriptomic studies.Biology of sex differences · 2022Pooled it
- Interferon-induced transmembrane protein 3 gene polymorphisms are associated with COVID-19 susceptibility and severity: A meta-analysis.The Journal of infection · 2022Pooled it
- Article
- Hospital-treated infection associated with Alzheimer's disease pathology: underlying mechanisms.Molecular psychiatry · 2026Review
- Increased Amyloidogenic Neuronal Injury in HIV-1-infected APP-KI Alzheimer's disease mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- DNA Sensing Pathways in Innate Immunity: Implications for Alzheimer's Disease Progression and Therapy.Molecular neurobiology · 2026Review
- Article
- TNF-α induces type I IFN signalling to suppress neurogenesis and recruit T cells.Nature communications · 2026Article
- Targeting inflammaging in Alzheimer's disease: molecular pathways and emerging pharmacotherapies.Inflammopharmacology · 2026Review
- Dual Physiological Barriers Bypassed by a Silk-Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Kilovoltage Energy Significantly Enhances the Therapeutic Efficacy of Low-Dose Radiation in a 3xTg-AD Mouse Model of Alzheimer's Disease.International journal of molecular sciences · 2026Article
- Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer's disease pathogenesis.Neuron · 2026Article
- Neuroinflammation and Secretase Regulation in Alzheimer's Disease: From Molecular Cross-Talk to Multi-Target Therapeutics.International journal of molecular sciences · 2026Review
- Mesenchymal stromal cells and neuroinflammation: a multimodal approach to neuroprotection and future therapeutic horizons.Translational neurodegeneration · 2026Review
- Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states.Nature communications · 2026Article
- MYCT1-IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion.The Journal of experimental medicine · 2026Article
- Type-1 interferons associated with microglial-mediated neuroinflammation in Alzheimer's disease.Journal of neuroinflammation · 2026Review
- 10-Hydroxy-2-decenoic Acid Attenuates Colitis-Associated Cognitive Dysfunction via IFITM3-Related Gut-Brain Axis Inflammation.Journal of agricultural and food chemistry · 2026Article
- Constructing Neuroinflammation-On-A-Chip for Traditional Chinese Medicine Extracts Evaluation.Smart medicine · 2026Article
175 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
31 authors at 6 institutions in 1 country.
Ji-Yeun Hur *Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Georgia R Frost *Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Xianzhong WuChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Christina CrumpChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Si Jia PanChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Eitan WongChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Marilia BarrosChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Thomas LiChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Pengju NieChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yujia ZhaiChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jen Chyong WangRonald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Julia TcwRonald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-3054-9374
Lei GuoDepartment of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew McKenzieDepartment of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chen MingDepartment of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-3295-301X
Xianxiao ZhouDepartment of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-9350-4467
Minghui WangDepartment of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-9171-4962
Yotam SagiLaboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA.
Alan E RentonRonald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-6702-8268
Bianca T EspositoRonald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yong KimLaboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA.
Katherine R SadleirFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Ivy TrinhDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Robert A RissmanDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Robert VassarFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Bin ZhangDepartment of Genetics and Genomic Sciences, Mount Sinai Center for Transformative Disease Modeling, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Douglas S JohnsonPfizer Worldwide Research and Development, Cambridge, MA, USA.
Eliezer MasliahDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Paul GreengardLaboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY, USA.
Alison GoateRonald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-0576-2472
Yue-Ming LiChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. liy2@mskcc.org.ORCID http://orcid.org/0000-0002-2633-3730
Icahn School of Medicine at Mount Sinai · USMemorial Sloan Kettering Cancer Center · USRockefeller University · USUniversity of California San Diego · USNorthwestern University · USPfizer (United States) · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MUCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DOUGLAS R GALASKO · 2019 to 2026
$34.9MIntegrative Network Biology Approaches to Identify, Characterize and Validate Molecular Subtypes in Alzheimer's DiseaseU01AG046170 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WANG, MINGHUI, ZHANG, BIN · 2013 to 2022
$26.0MIntegrative Network Modeling of Cognitive Resilience to Alzheimer's DiseaseR01AG057907 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, HAROUTUNIAN, VAHRAM · 2017 to 2021
$6.3MB-Synuclein as a Treatment for Lewy Body DiseaseR01AG018440 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RISSMAN, ROBERT · 2001 to 2021
$5.2MRegulation of y-secretase activity by modulatory proteinsR01AG061350 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI LI, YUEMING · 2019 to 2023
$4.3MTowards a comprehensive signaling pathway map of parahippocampal vulnerability in Alzheimers DiseaseRF1AG057440 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HAROUTUNIAN, VAHRAM, NOGGLE, SCOTT ALLEN · 2017 to 2017
$3.5MRegulation and Function of Gamma-SecretaseR01AG026660 · NIA · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI LI, YUEMING · 2005 to 2015
$3.5MSubstrate Feedback Mechanism of gamma-SecretaseRF1AG057593 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI LI, YUEMING · 2018 to 2018
$2.1MMechanism and Synergy of gamma-Secretase ModulatorsR01NS096275 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI LI, YUEMING · 2016 to 2020
$2.1MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MNCI NIH HHS P30 CA008748NIA NIH HHS K01 AG062683NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG006170NIA NIH HHS R01 AG018440NIA NIH HHS R01 AG026660NIA NIH HHS R01 AG057907NIA NIH HHS R01 AG061350NIA NIH HHS RF1 AG057440NIA NIH HHS RF1 AG057593NIA NIH HHS U01 AG046170NIH HHS S10 OD018522NIH HHS S10 OD026880NINDS NIH HHS R01 NS096275
Abstract
Innate immunity is associated with Alzheimer's disease
Indexed as
Immunity, InnateAged, 80 and overAge of OnsetAgingAlzheimer DiseaseAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAnimalsAstrocytesCatalytic DomainDisease Models, AnimalFemaleHEK293 CellsHumansInflammationMaleAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAPP protein, humanIFITM3 protein, humanMembrane ProteinsPresenilin-1PSEN1 protein, humanRNA-Binding Proteins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.