ArticleNature2020
Violet-light suppression of thermogenesis by opsin 5 hypothalamic neurons.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06094504 (Impact of Full Spectrum Light on Outcomes of Infants With Intestinal Failure), which is not on this map. Cited by 92 papers.
0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
8.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT06094504 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation
Impact of Full Spectrum Light on Outcomes of Infants With Intestinal Failure
Who cites it
92 citing papers in PubMed, 149 citations in OpenAlex.
- Thermal challenge and food intake: Mutual regulatory mechanisms.Neural regeneration research · 2026Article
- Neural Control of Homeothermy, Torpor, and Hibernation.Annual review of neuroscience · 2026Review
- A distinct vagus-beta cell neural circuit senses glucose and modulates insulin secretion.Molecular metabolism · 2026Article
- GABAergic projections from the suprachiasmatic nucleus to the preoptic area regulate the timing of torpor in mice.Nature communications · 2026Article
- Opposing Roles of OPN3 and OPN5 Affecting the Intrinsic Pupillary Light Reflex of the Mammalian Iris.Investigative ophthalmology & visual science · 2026Article
- Temperature as a Metabolic Signal Linking Neural and Endocrine Circuits to Energy Homeostasis.International journal of molecular sciences · 2026Review
- Wavelength-dependent sleep state manipulation using light pulses in Pogona vitticeps.Communications biology · 2026Article
- Estrous cycle modulates fasting-induced torpor propensity via hypothalamic estrogen signalling.Scientific reports · 2026Article
- Obesogenic effects of warm temperature involve feeding adaptation by preoptic area leptin receptor neurons.Communications biology · 2026Article
- Light and myopia: a focus on the expanding role of non-visual opsins.Eye and vision (London, England) · 2026Review
- Non-visual opsins and their role in circadian photoentrainment.Eye and vision (London, England) · 2026Review
- A novel theory of rapid eye movement sleep as an integral component of the seasonal timekeeping apparatus.Frontiers in neuroscience · 2026Article
- The physiological functions of OPN5m.Eye and vision (London, England) · 2025Review
- IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies.Investigative ophthalmology & visual science · 2025Review
- Blue Light Defocus Induces A Positive Effect on Refractive Status and Ocular Health: A Randomized Crossover Trial.Global challenges (Hoboken, NJ) · 2025Article
- Non-visual photoreceptive brain specification in sea urchin larvae.Nature communications · 2025Article
- Discovery and design of photocyclic animal opsins: potential application to gene therapy from non-visual opsin research.Eye and vision (London, England) · 2025Review
- Article
- Artificially induced torpor during pregnancy impairs fetal growth in mice.Scientific reports · 2025Article
- A key spectral tuning site of UV-sensitive vertebrate non-visual opsin Opn5.Cellular and molecular life sciences : CMLS · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 1 country.
Kevin X ZhangThe Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-6028-6536
Shane D'SouzaThe Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0001-6344-1434
Brian A UptonThe Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0003-4544-6869
Stace KernodleDepartment of Surgery, University of Michigan, School of Public Health, Ann Arbor, MI, USA.
Shruti VemarajuThe Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Gowri NayakThe Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-5106-5192
Kevin D GaitondeThe Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-2536-5132
Amanda L HoltDepartment of Physics, Yale University, New Haven, CT, USA.
Courtney D LinneThe Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0002-2493-8197
April N SmithThe Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Nathan T PettsDivision of Clinical Engineering, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Matthew BatieDivision of Clinical Engineering, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Rajib MukherjeeDivision of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Durgesh TiwariDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Ethan D BuhrDepartment of Ophthalmology, University of Washington Medical School, Seattle, WA, USA.
Russell N Van GelderDepartment of Ophthalmology, University of Washington Medical School, Seattle, WA, USA.
Christina GrossDivision of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0001-6057-2527
Alison SweeneyDepartment of Physics, Yale University, New Haven, CT, USA.
Joan Sanchez-GurmachesDivision of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0003-1854-7832
Randy J SeeleyDepartment of Surgery, University of Michigan, School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3721-5625
Richard A LangThe Visual Systems Group, Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Richard.Lang@cchmc.org.ORCID http://orcid.org/0000-0002-5212-254X
Cincinnati Children's Hospital Medical Center · USUniversity of Michigan · USYale University · USUniversity of Washington · USUniversity of Washington Medical Center · US
Funding
Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 1985 to 2026
$23.5MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3MMedical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7MFunctions of OPN5 and OPN3 in the eyeR01EY026921 · NEI · UNIVERSITY OF WASHINGTON · PI VAN GELDER, RUSSELL N., YAU, KING-WAI · 2017 to 2021
$2.8MRegulation of vascular development in the eye by an opsin 5-dependent clockR01EY027077 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A., RAO, SUJATA · 2016 to 2020
$2.4MRegulation of eye development by an Opsin5-dopamine pathwayR01EY027711 · NEI · EMORY UNIVERSITY · PI IUVONE, P MICHAEL, LANG, RICHARD A. · 2017 to 2020
$1.9MThe role of OPN5 in extraocular circadian photoentrainment in mammalsR01GM124246 · NIGMS · UNIVERSITY OF WASHINGTON · PI BUHR, ETHAN D · 2017 to 2021
$1.9MLight regulated vascular development in the eye via the Hippo pathwayR01EY032029 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI LANG, RICHARD A., XIN, MEI · 2021 to 2024
$1.6MAmerican Heart Association-American Stroke Association 18CDA34080527NEI NIH HHS P30 EY001730NEI NIH HHS R01 EY026921NEI NIH HHS R01 EY027077NEI NIH HHS R01 EY027711NEI NIH HHS R01 EY032029NIDDK NIH HHS P30 DK089503NIGMS NIH HHS 5T32GM063483NIGMS NIH HHS R01 GM124246NIGMS NIH HHS T32 GM063483
Abstract
The opsin family of G-protein-coupled receptors are used as light detectors in animals. Opsin 5 (also known as neuropsin or OPN5) is a highly conserved opsin that is sensitive to visible violet light
Indexed as
ColorLightAdipose Tissue, BrownAnimalsBody TemperatureCold TemperatureCyclic AMPFemaleMaleMembrane ProteinsMiceNeuronsOpsinsPreoptic AreaThermogenesisCyclic AMPMembrane ProteinsOPN5 protein, mouseOpsins
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT06094504ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.