Evidence map›Paper›PMID 32879441›Full record

ArticleJournal of human genetics2021

Aberrant expression of a novel circular RNA in pancreatic cancer.

Takahiro Seimiya, Motoyuki Otsuka, Takuma Iwata, Eri Tanaka, Kazuma Sekiba, Chikako Shibata, Masaru Moriyama, Ryo Nakagawa, Reo Maruyama, Kazuhiko Koike

Abstract read
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In one paragraph

Article in Journal of human genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Catching pancreatic cancer early: Are we there yet?Journal of the National Cancer Center · 2026
    Review
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  16. Liquid biopsy approach to pancreatic cancer.World journal of gastrointestinal oncology · 2021
    Review
  17. Current State of "Omics" Biomarkers in Pancreatic Cancer.Journal of personalized medicine · 2021
    Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Takahiro SeimiyaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Motoyuki OtsukaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan. otsukamo-tky@umin.ac.jp.ORCID http://orcid.org/0000-0003-2869-2881
Takuma IwataDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Eri TanakaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Kazuma SekibaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.ORCID http://orcid.org/0000-0002-9429-1974
Chikako ShibataDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Masaru MoriyamaOmiya City Clinic, Saitama, 330-8669, Japan.
Ryo NakagawaOmiya City Clinic, Saitama, 330-8669, Japan.
Reo MaruyamaProject for Cancer Epigenomics, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, 135-8550, Japan.
Kazuhiko KoikeDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
The University of Tokyo · JPJapanese Foundation For Cancer Research · JP

Funding

Japan Agency for Medical Research and Development (AMED) JP19cm0106602
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are single-stranded, covalently closed RNA molecules that are produced from pre-mRNAs through a process known as back-splicing. Although circRNAs are expressed under specific conditions, current understanding of their comprehensive expression status is still limited. Here, we performed a large-scale circRNA profiling analysis in human pancreatic ductal adenocarcinoma (PDAC) tissues, using circular RNA-specific RNA sequencing. We identified more than 40,000 previously unknown circRNAs, some of which were upregulated in PDAC tissues, compared with normal pancreatic tissues. We determined the full-length sequence of a circRNA upregulated in PDAC, which was derived from two noncoding RNA loci on chromosome 12. The novel circRNA, named circPDAC RNA, was not expressed in normal human cells, but was expressed in PDAC and other carcinoma cells. While postulated biological functions, such as peptide production from the circPDAC RNA, were not detected, its aberrant expression was confirmed in other PDAC tissues and in serum from a PDAC patient. These results demonstrate that comprehensive studies are necessary to reveal the expression status of circRNAs and that the circPDAC RNA identified here might serve as a novel biomarker for cancers, including PDAC.

Indexed as

Gene Expression Regulation, NeoplasticBiomarkers, TumorCarcinoma, Pancreatic DuctalCase-Control StudiesGene Expression ProfilingHumansPancreatic NeoplasmsRNA, CircularSequence Analysis, RNATumor Cells, CulturedBiomarkers, TumorRNA, Circular

Identifiers

PMID32879441
OpenAlexW3081840801

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.