Evidence map›Paper›PMID 32879387›Full record

ArticleScientific reports2020

Changes in γH2AX and H4K16ac levels are involved in the biochemical response to a competitive soccer match in adolescent players.

Katarzyna Kozioł, Jacek Zebrowski, Gabriela Betlej, Ewelina Bator, Wojciech Czarny, Wojciech Bajorek, Bartłomiej Czarnota, Robert Czaja, Paweł Król, Aleksandra Kwiatkowska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Katarzyna KoziołDepartment of Animal Physiology and Reproduction, University of Rzeszów, Werynia 502, 36-100, Kolbuszowa, Poland.
Jacek ZebrowskiInstitute of Biology and Biotechnology, University of Rzeszów, Aleja Rejtana 16c, 35-959, Rzeszów, Poland.
Gabriela BetlejLaboratory of Exercise Physiology and Biochemistry, Institute of Physical Culture Studies, College of Medical Sciences, University of Rzeszów, Aleja Rejtana 16c, 35-959, Rzeszów, Poland.
Ewelina BatorLaboratory of Exercise Physiology and Biochemistry, Institute of Physical Culture Studies, College of Medical Sciences, University of Rzeszów, Aleja Rejtana 16c, 35-959, Rzeszów, Poland.
Wojciech CzarnyInstitute of Physical Culture Studies, College of Medical Sciences, University of Rzeszów, Aleja Rejtana 16c, 35-959, Rzeszów, Poland.
Wojciech BajorekInstitute of Physical Culture Studies, College of Medical Sciences, University of Rzeszów, Aleja Rejtana 16c, 35-959, Rzeszów, Poland.
Bartłomiej CzarnotaDepartment of Swimming Sports, Institute of Physical Culture Studies, College of Medical Sciences, University of Rzeszów, Aleja Rejtana 16c, 35-959, Rzeszów, Poland.
Robert CzajaInstitute of Physical Culture Studies, College of Medical Sciences, University of Rzeszów, Aleja Rejtana 16c, 35-959, Rzeszów, Poland.
Paweł KrólInstitute of Physical Culture Studies, College of Medical Sciences, University of Rzeszów, Aleja Rejtana 16c, 35-959, Rzeszów, Poland.
Aleksandra KwiatkowskaLaboratory of Exercise Physiology and Biochemistry, Institute of Physical Culture Studies, College of Medical Sciences, University of Rzeszów, Aleja Rejtana 16c, 35-959, Rzeszów, Poland. akwiatkowska@ur.edu.pl.ORCID http://orcid.org/0000-0003-4159-977X
University of Rzeszów · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to examine novel putative markers of the response to the competitive soccer match in adolescent players, such as changes in global levels of γH2AX and H4K16ac in the chromatin of peripheral mononuclear blood cells (PMBCs) and a Fourier-transform infrared spectroscopy (FTIR)-based biochemical fingerprint of serum. These characteristics were examined with reference to the physiological and metabolic aspects of this response. Immediately post-match we noticed: (1) a systemic inflammatory response, manifesting as peaks in leukocyte count and changes in concentrations of IL-6, TNFα, and cortisol; (2) a peak in plasma lactate; (3) onset of oxidative stress, manifesting as a decline in GSH/GSSG; (4) onset of muscle injury, reflected in an increase in CK activity. Twenty-four hours post-match the decrease in GSH/GSSG was accompanied by accumulation of MDA and 8-OHdG, macromolecule oxidation end-products, and an increase in CK activity. No changes in SOD1 or GPX1 levels were found. Repeated measures correlation revealed several associations between the investigated biomarkers. The FTIR analysis revealed that the match had the greatest impact on serum lipid profile immediately post-game. In turn, increases in γH2AX and H4K16ac levels at 24 h post-match indicated activation of a DNA repair pathway.

Indexed as

Athletic PerformanceAdolescentAnthropometryBiomarkersCreatine KinaseDNA RepairFemaleHistonesHumansHydrocortisoneInflammationInterleukin-6Lactic AcidLeukocytes, MononuclearMacromolecular SubstancesMaleBiomarkersCreatine KinaseHistonesHydrocortisoneIL6 protein, humanInterleukin-6Lactic AcidMacromolecular SubstancesTNF protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID32879387
PMCPMC7468116
OpenAlexW3081945160

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.