ArticleScientific reports2020
Sylvian fissure development is linked to differential genetic expression in the pre-folded brain.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- A simple and quantitative ultrasonographic screening method for fetal Sylvian fissure abnormalities.European journal of medical research · 2025Article
- Fetal malformations of cortical development: review and clinical guidance.Brain : a journal of neurology · 2025Review
- Sylvian fissure angle development on fetal MRI: 22-38 gestational weeks.Frontiers in neuroscience · 2025Article
- Interhemispheric axonal sprouting occurs after pial removal in mice.Scientific reports · 2024Article
- Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years.Nature · 2023Article
- Heterogeneous growth of the insula shapes the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates.Developmental cognitive neuroscience · 2023Review
- Three-Dimensional Crystal Vue Imaging technology assessment of Sylvian fissures at 20-32+6 weeks' normal gestation.European radiology · 2023Article
- Characterization of dynamic patterns of human fetal to neonatal brain asymmetry with deformation-based morphometry.Frontiers in neuroscience · 2023Article
- Comparative analysis of four nuclei in the human brainstem: Individual differences, left-right asymmetry, species differences.Frontiers in neuroanatomy · 2023Article
- Cadaveric White Matter Dissection Study of the Telencephalic Flexure: Surgical Implications.Frontiers in neurology · 2022Article
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Authors and funding
5 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The mechanisms by which the human cerebral cortex folds into its final form remain poorly understood. With most of the current models and evidence addressing secondary folds, we sought to focus on the global geometry of the mature brain by studying its most distinctive feature, the Sylvian fissure. A digital human fetal brain atlas was developed using previously obtained MRI imaging of 81 healthy fetuses between gestational ages 21 and 38 weeks. To account for the development of the Sylvian fissure, we compared the growth of the frontotemporal opercula over the insular cortex and compared the transcriptome of the developing cortices for both regions. Spatiotemporal mapping of the lateral hemispheric surface showed the highest rate of organized growth in regions bordering the Sylvian fissure of the frontal, parietal and temporal lobes. Volumetric changes were first observed in the posterior aspect of the fissure moving anteriorly to the frontal lobe and laterally in the direction of the temporal pole. The insular region, delineated by the limiting insular gyri, expanded to a much lesser degree. The gene expression profile, before folding begins in the maturing brain, was significantly different in the developing opercular cortex compared to the insula. The Sylvian fissure forms by the relative overgrowth of the frontal and temporal lobes over the insula, corresponding to domains of highly expressed transcription factors involved in neuroepithelial cell differentiation.
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