Evidence map›Paper›PMID 32879364›Full record

ArticleScientific reports2020

A deep learning approach in diagnosing fungal keratitis based on corneal photographs.

Ming-Tse Kuo, Benny Wei-Yun Hsu, Yu-Kai Yin, Po-Chiung Fang, Hung-Yin Lai, Alexander Chen, Meng-Shan Yu, Vincent S Tseng

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  5. Article
  6. Review
  7. Review
  8. Article
  9. Artificial intelligence in corneal diseases: A narrative review.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. The Emergence Potential ofArchives of Razi Institute · 2024
    Review
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  17. Article
  18. Article
  19. Artificial intelligence in the anterior segment of eye diseases.International journal of ophthalmology · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ming-Tse Kuo *Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist., Kaohsiung, 833, Taiwan, ROC. mingtse@cgmh.org.tw.
Benny Wei-Yun Hsu *Department of Computer Science, National Chiao Tung University, No. 1001, Daxue Rd., East Dist., Hsinchu, 300, Taiwan, ROC.
Yu-Kai YinDepartment of Computer Science, National Chiao Tung University, No. 1001, Daxue Rd., East Dist., Hsinchu, 300, Taiwan, ROC.
Po-Chiung FangDepartment of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist., Kaohsiung, 833, Taiwan, ROC.
Hung-Yin LaiDepartment of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist., Kaohsiung, 833, Taiwan, ROC.
Alexander ChenDepartment of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist., Kaohsiung, 833, Taiwan, ROC.
Meng-Shan YuDepartment of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist., Kaohsiung, 833, Taiwan, ROC.
Vincent S TsengDepartment of Computer Science, National Chiao Tung University, No. 1001, Daxue Rd., East Dist., Hsinchu, 300, Taiwan, ROC. vtseng@cs.nctu.edu.tw.
Chang Gung University · TWNational Yang Ming Chiao Tung University · TWKaohsiung Chang Gung Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungal keratitis (FK) is the most devastating and vision-threatening microbial keratitis, but clinical diagnosis a great challenge. This study aimed to develop and verify a deep learning (DL)-based corneal photograph model for diagnosing FK. Corneal photos of laboratory-confirmed microbial keratitis were consecutively collected from a single referral center. A DL framework with DenseNet architecture was used to automatically recognize FK from the photo. The diagnoses of FK via corneal photograph for comparing DL-based models were made in the Expert and NCS-Oph group through a majority decision of three non-corneal specialty ophthalmologist and three corneal specialists, respectively. The average percentage of sensitivity, specificity, positive predictive value, and negative predictive value was approximately 71, 68, 60, and 78. The sensitivity was higher than that of the NCS-Oph (52%, P < .01), whereas the specificity was lower than that of the NCS-Oph (83%, P < .01). The average accuracy of around 70% was comparable with that of the NCS-Oph. Therefore, the sensitive DL-based diagnostic model is a promising tool for improving first-line medical care at rural area in early identification of FK.

Indexed as

Deep LearningCorneaCorneal UlcerEye Infections, FungalHumansOptical ImagingPhotographySensitivity and Specificity

Identifiers

PMID32879364
PMCPMC7468230
OpenAlexW3082939062

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.