Evidence map›Paper›PMID 32879333›Full record

Trial reportScientific reports2020

Serum Midkine, estimated glomerular filtration rate and chronic kidney disease-related events in elderly women: Perth Longitudinal Study of Aging Women.

Jeffrey Wang, Joshua R Lewis, Elizabeth Byrnes, Germaine Wong, Warren D Raymond, Kun Zhu, Graham R Robertson, Wai H Lim, Qi Cao, Richard L Prince and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Jeffrey Wang *Centre for Transplant and Renal Research, University of Sydney at Westmead Institute of Medical Research, Westmead, 2145, Australia. jwan3534@uni.sydney.edu.au.
Joshua R Lewis *Centre for Kidney Research, Children's Hospital at Westmead School of Public Health, Sydney Medical School, The University of Sydney, Sydney, 2006, Australia.
Elizabeth Byrnes *PathWest, QEII Medical Centre, Perth, 6009, Australia.
Germaine WongCentre for Kidney Research, Children's Hospital at Westmead School of Public Health, Sydney Medical School, The University of Sydney, Sydney, 2006, Australia.
Warren D RaymondSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, Australia.
Kun ZhuFaculty of Health and Medical Sciences, The University of Western Australia, Perth, 6009, Australia.
Graham R RobertsonLyramid Limited, Sydney, 2000, Australia.
Wai H LimFaculty of Health and Medical Sciences, The University of Western Australia, Perth, 6009, Australia.
Qi CaoCentre for Transplant and Renal Research, University of Sydney at Westmead Institute of Medical Research, Westmead, 2145, Australia.
Richard L PrinceFaculty of Health and Medical Sciences, The University of Western Australia, Perth, 6009, Australia.
Vincent W LeeCentre for Transplant and Renal Research, University of Sydney at Westmead Institute of Medical Research, Westmead, 2145, Australia.
University of Western Australia · AUWestmead Institute · AUChildren's Hospital at Westmead · AUQueen Elizabeth II Medical Centre · AUSir Charles Gairdner Hospital · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Midkine (MDK), a heparin-binding growth factor cytokine, is involved in the pathogenesis of kidney diseases by augmenting leukocyte trafficking and activation. Animal models and small case control studies have implicated MDK as a pathological biomarker in chronic kidney diseases (CKD), however this is yet to be confirmed in prospective human studies. In a prospective study of 499 elderly, predominantly Caucasian women aged over 70 years the association between serum MDK collected in 1998, and renal function change and the risk of CKD-related hospitalisations and deaths at 5 and 14.5 years, respectively, was examined. Baseline serum MDK was not associated with 5-year change in estimated glomerular filtration rate using the CKD Epidemiology Collaboration creatinine and cystatin C equation (Standardised β = - 0.09, 95% confidence interval - 3.76-0.48, p = 0.129), 5-year rapid decline in renal function (odds ratio = 0.97, 95% confidence interval 0.46-2.02, p = 0.927) or the risk of 14.5-year CKD-related hospitalisations and deaths (hazard ratio = 1.27, 95% confidence interval .66-2.46, p = 0.470) before or after adjusting for major risk factors. In conclusion, in this cohort of elderly women with normal or mildly impaired renal function, serum MDK was not associated with renal function change or future CKD-related hospitalisations and deaths, suggesting that MDK may not be an early biomarker for progression of CKD.

Indexed as

Glomerular Filtration RateAgedAgingBiomarkersDisease ProgressionFemaleHumansKidney Failure, ChronicLongitudinal StudiesMidkineMultivariate AnalysisPrognosisProportional Hazards ModelsProspective StudiesRisk FactorsWestern AustraliaBiomarkersMDK protein, humanMidkine

Identifiers

PMID32879333
PMCPMC7468100
OpenAlexW3081980689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.