Evidence map›Paper›PMID 32879325›Full record

ArticleScientific reports2020

An altered glial phenotype in the NL3

Samantha M Matta, Zachery Moore, Frederick Rohan Walker, Elisa L Hill-Yardin, Peter J Crack

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

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  10. Astroglia in Autism Spectrum Disorder.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Samantha M MattaDepartment of Pharmacology and Therapeutics, The University of Melbourne, Grattan St, Parkville, VIC, Australia.
Zachery MooreDepartment of Pharmacology and Therapeutics, The University of Melbourne, Grattan St, Parkville, VIC, Australia.
Frederick Rohan WalkerSchool of Biomedical Sciences and Pharmacy, University of Newcastle, University Drive, Callaghan, NSW, Australia.
Elisa L Hill-Yardin *School of Health & Biomedical Sciences, RMIT University, 225-245 Clements Drive, Bundoora, VIC, Australia.
Peter J Crack *Department of Pharmacology and Therapeutics, The University of Melbourne, Grattan St, Parkville, VIC, Australia. pcrack@unimelb.edu.au.
University of Melbourne · AUHunter Medical Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD; autism) is a neurodevelopmental disorder characterised by deficits in social communication, and restricted and/or repetitive behaviours. While the precise pathophysiologies are unclear, increasing evidence supports a role for dysregulated neuroinflammation in the brain with potential effects on synapse function. Here, we studied characteristics of microglia and astrocytes in the Neuroligin-3 (NL3

Indexed as

AnimalsAstrocytesAutistic DisorderCell Adhesion Molecules, NeuronalDisease Models, AnimalDisks Large Homolog 4 ProteinFemaleHippocampusImmunohistochemistryInflammationMaleMembrane ProteinsMiceMice, Inbred C57BLMicrogliaNerve Tissue ProteinsCell Adhesion Molecules, NeuronalDisks Large Homolog 4 ProteinDlg4 protein, mouseMembrane ProteinsNerve Tissue Proteinsneuroligin 3Snap25 protein, mouseSynaptosomal-Associated Protein 25

Identifiers

PMID32879325
PMCPMC7468159
OpenAlexW3081548601

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.