ArticleNPJ schizophrenia2020
Functional brain networks in the schizophrenia spectrum and bipolar disorder with psychosis.
Article in NPJ schizophrenia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
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Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- EANM perspective on clinical PET and SPECT imaging in schizophrenia-spectrum disorders: a systematic review of longitudinal studies.European journal of nuclear medicine and molecular imaging · 2025Pooled it
- Pooled it
- Transdiagnostic markers across the psychosis continuum: a systematic review and meta-analysis of resting state fMRI studies.Frontiers in psychiatry · 2024Pooled it
- A meta-analysis and systematic review of single vs. multimodal neuroimaging techniques in the classification of psychosis.Molecular psychiatry · 2023Pooled it
- Meta-analytic evidence of elevated choline, reduced N-acetylaspartate, and normal creatine in schizophrenia and their moderation by measurement quality, echo time, and medication status.NeuroImage. Clinical · 2023Pooled it
- Functional Coupling and Longitudinal Outcome Prediction in First-Episode Psychosis.Biological psychiatry global open science · 2025Article
- Altered Brain-Behavior Association During Resting State is a Potential Psychosis Risk Marker.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Parsing disease heterogeneity in structural and functional MRI-derived measures using normative modeling and Generative Adversarial Networks (GANs).Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- A comparative machine learning study of schizophrenia biomarkers derived from functional connectivity.Scientific reports · 2025Article
- Minimum spanning tree analysis of EEG resting-state functional networks in schizophrenia.Scientific reports · 2024Article
- Divergent pattern of functional connectivity within the dorsal attention network differentiates schizophrenia and bipolar disorder patients.Frontiers in psychiatry · 2024Article
- Abnormal Spatial and Temporal Overlap of Time-Varying Brain Functional Networks in Patients with Schizophrenia.Brain sciences · 2023Article
- Dorsal attention network activity during perceptual organization is distinct in schizophrenia and predictive of cognitive disorganization.The European journal of neuroscience · 2023Article
- Minimum spanning tree analysis of brain networks: A systematic review of network size effects, sensitivity for neuropsychiatric pathology, and disorder specificity.Network neuroscience (Cambridge, Mass.) · 2022Article
- Chaos analysis of the brain topology in first-episode psychosis and clinical high risk patients.Frontiers in psychiatry · 2022Article
- Abnormality of Functional Connections in the Resting State Brains of Schizophrenics.Frontiers in human neuroscience · 2022Article
- Lower Hippocampal Volume in Patients with Schizophrenia and Bipolar Disorder: A Quantitative MRI Study.Journal of personalized medicine · 2021Article
- Electroencephalographic Microstates in Schizophrenia and Bipolar Disorder.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Psychotic experiences have been proposed to lie on a spectrum, ranging from subclinical experiences to treatment-resistant schizophrenia. We aimed to characterize functional connectivity and brain network characteristics in relation to the schizophrenia spectrum and bipolar disorder with psychosis to disentangle neural correlates to psychosis. Additionally, we studied antipsychotic medication and lithium effects on network characteristics. We analyzed functional connectivity strength and network topology in 487 resting-state functional MRI scans of individuals with schizophrenia spectrum disorder (SCZ), bipolar disorder with a history of psychotic experiences (BD), treatment-naïve subclinical psychosis (SCP), and healthy controls (HC). Since differences in connectivity strength may confound group comparisons of brain network topology, we analyzed characteristics of the minimum spanning tree (MST), a relatively unbiased backbone of the network. SCZ and SCP subjects had a lower connectivity strength than BD and HC individuals but showed no differences in network topology. In contrast, BD patients showed a less integrated network topology but no disturbances in connectivity strength. No differences in outcome measures were found between SCP and SCZ, or between BD patients that used antipsychotic medication or lithium and those that did not. We conclude that functional networks in patients prone to psychosis have different signatures for chronic SCZ patients and SCP compared to euthymic BD patients, with a limited role for medication. Connectivity strength effects may have confounded previous studies, as no functional network alterations were found in SCZ after strict correction for connectivity strength.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.