Evidence map›Paper›PMID 32878928›Full record

ArticlemSphere2020

Antibody and Local Cytokine Response to Respiratory Syncytial Virus Infection in Community-Dwelling Older Adults.

Xiao Yu, Anke J Lakerveld, Sandra Imholz, Marion Hendriks, Sofie C A Ten Brink, H Lie Mulder, Karen de Haan, Rutger M Schepp, Willem Luytjes, Menno D de Jong and 2 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Frontiers in immunology · 2021
    Pooled it
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  3. Article
  4. Review
  5. Article
  6. Article
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  11. Article
  12. Experimental and therapeutic medicine · 2022
    Article
  13. Review
  14. Asthma-Associated Long TSLP Inhibits the Production of IgA.International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Xiao YuLaboratory of Clinical Virology, Department of Medical Microbiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Anke J LakerveldCenter for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.ORCID 0000-0002-4386-3995
Sandra ImholzCenter for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Marion HendriksCenter for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Sofie C A Ten BrinkLaboratory of Clinical Virology, Department of Medical Microbiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
H Lie MulderCenter for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Karen de HaanLaboratory of Clinical Virology, Department of Medical Microbiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Rutger M ScheppCenter for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Willem LuytjesCenter for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Menno D de JongLaboratory of Clinical Virology, Department of Medical Microbiology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Josine van BeekCenter for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Puck B van KasterenCenter for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands Puck.van.Kasteren@rivm.nl.ORCID 0000-0003-4369-6055
National Institute for Public Health and the Environment · NLUniversity of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is increasingly recognized for causing severe morbidity and mortality in older adults, but there are few studies on the RSV-induced immune response in this population. Information on the immunological processes at play during RSV infection in specific risk groups is essential for the rational and targeted design of novel vaccines and therapeutics. Here, we assessed the antibody and local cytokine response to RSV infection in community-dwelling older adults (≥60 years of age). During three winters, serum and nasopharyngeal swab samples were collected from study participants during acute respiratory infection and recovery. RSV IgG enzyme-linked immunosorbent assays (ELISA) and virus neutralization assays were performed on serum samples from RSV-infected individuals (

Indexed as

AgedAged, 80 and overAge FactorsAnimalsAntibodies, ViralBronchiCell LineChlorocebus aethiopsCytokinesEpithelial CellsFemaleHumansMaleMiddle AgedRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsAntibodies, ViralCytokinescytokineelderlyIgAIgGinterferonmucosa

Identifiers

PMID32878928
PMCPMC7471002
OpenAlexW3082825989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.