Evidence map›Paper›PMID 32878897›Full record

ArticleJournal of virology2020

Emergence and Magnitude of ML336 Resistance in Venezuelan Equine Encephalitis Virus Depend on the Microenvironment.

Jasper Lee, Jyothi Parvathareddy, Dong Yang, Shruti Bansal, Kathryn O'Connell, Jennifer E Golden, Colleen B Jonsson

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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  10. Virtual andACS pharmacology & translational science · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jasper LeeDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Jyothi ParvathareddyRegional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Dong YangRegional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Shruti BansalRegional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Kathryn O'ConnellLaboratory Animal Care Unit, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Jennifer E GoldenPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-6813-3710
Colleen B JonssonDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA cjonsson@uthsc.edu.ORCID 0000-0002-2640-7672
University of Tennessee Health Science Center · USUniversity of Wisconsin–Madison · US

Funding

Medicinal Chemistry Optimization of Anti-Alphaviral Leads and Elucidation of Target and Off Target EngagementU19AI142762 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JONSSON, COLLEEN B · 2019 to 2023
$22.0M
Lead Optimization of ML336, a Potent VEEV InhibitorR01AI118814 · NIAID · UNIVERSITY OF LOUISVILLE · PI CHUNG, DONGHOON, GOLDEN, JENNIFER E. · 2015 to 2019
$2.8M
NIAID NIH HHS R01 AI118814NIAID NIH HHS U19 AI142762
6 · The paper itself

Abstract

Venezuelan equine encephalitis virus (VEEV) is a New World

Indexed as

AnimalsAntiviral AgentsBenzamidesCell LineChlorocebus aethiopsDrug Resistance, ViralEncephalitis Virus, Venezuelan EquineEncephalomyelitis, Venezuelan EquineHigh-Throughput Nucleotide SequencingHumansMutationPiperazinesPolymorphism, Single NucleotideVero CellsViral Proteins2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamideAntiviral AgentsBenzamidesPiperazinesViral ProteinsAlphavirusantiviral agentsML336next-generation sequencingVenezuelan encephalitis virus

Identifiers

PMID32878897
PMCPMC7592223
OpenAlexW3083070239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.