Evidence map›Paper›PMID 32878764›Full record

ArticleBMJ open2020

Intensive Care Weaning (iCareWean) protocol on weaning from mechanical ventilation: a single-blinded multicentre randomised control trial comparing an open-loop decision support system and routine care, in the general intensive care unit.

M P Vizcaychipi, Laura Martins, James R White, Dan Stleper Karbing, Amandeep Gupta, Suveer Singh, Leyla Osman, Jeronimo Moreno-Cuesta, Steve Rees

Erratum issued Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03249623 (Weaning From Mechanical Ventilation), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03249623 naunknown statusnot on this map

Weaning From Mechanical Ventilation: Comparison of Open-Loop Decision Support System and Routine Care, in the General Intensive Care Unit

TypeinterventionalSponsorChelsea and Westminster NHS Foundation TrustRan2017 to 2021Enrolled274ConditionsVentilatory FailureArmsBeacon Caresystem
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

M P VizcaychipiAPMIC, Imperial College London, London, UK m.vizcaychipi@imperial.ac.uk.ORCID 0000-0001-7894-873X
Laura MartinsResearch Trial Unit, Chelsea and Westminster Hospital NHS Foundation Trust, London, London, UK.
James R WhiteMagill Department of Anaesthesia, Chelsea and Westminster Hospital NHS Foundation Trust, London, London, UK.
Dan Stleper KarbingCenter for Model-based Medical Decision Support, Aalborg Universitet, Aalborg, Denmark.
Amandeep GuptaAnaesthetic Department, West Middlesex University Hospital NHS Trust, London, London, UK.
Suveer SinghMagill Department of Anaesthesia and Intensive Care Medicine, Chelsea and Westminster Healthcare NHS Trust, London, UK.
Leyla OsmanMagill Department of Anaesthesia, Chelsea and Westminster Hospital NHS Foundation Trust, London, London, UK.
Jeronimo Moreno-CuestaAnaesthetic Department, North Middlesex University Hospital NHS Trust, London, London, UK.
Steve ReesDepartment of Health Science and Technology, Aalborg Universitet Institut for Medicin og Sundhedsteknologi, Aalborg, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAutomated systems for ventilator management to date have been either fully heuristic rule-based systems or based on a combination of simple physiological models and rules. These have been shown to reduce the duration of mechanical ventilation in simple to wean patients. At present, there are no published studies that evaluate the effect of systems that use detailed physiological descriptions of the individual patient.The BEACON Caresystem is a model-based decision support system that uses mathematical models of patients' physiology in combination with models of clinical preferences to provide advice on appropriate ventilator settings. An individual physiological description may be particularly advantageous in selecting the appropriate therapy for a complex, heterogeneous, intensive care unit (ICU) patient population. METHODS AND ANALYSIS: Intenive Care weaning (iCareWean) is a single-blinded, multicentre, prospective randomised control trial evaluating management of mechanical ventilation as directed by the BEACON Caresystem compared with that of current care, in the general intensive care setting. The trial will enrol 274 participants across multiple London National Health Service ICUs. The trial will use a primary outcome of duration of mechanical ventilation until successful extubation. ETHICS AND DISSEMINATION: Safety oversight will be under the direction of an independent committee of the study sponsor. Study approval was obtained from the regional ethics committee of the Health Research Authority (HRA), (Research Ethic Committee (REC) reference: 17/LO/0887. Integrated Research Application System (IRAS) reference: 226610. Results will be disseminated through international critical care conference/symposium and publication in peer-reviewed journal. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov under NCT03249623. This research is registered with the National Institute for Health Research under CPMS ID: 34831.

Indexed as

Respiration, ArtificialState MedicineCritical CareHumansIntensive Care UnitsLondonMulticenter Studies as TopicProspective StudiesRandomized Controlled Trials as TopicVentilator Weaningadult intensive & critical carephysiologyrespiratory medicine (see thoracic medicine)

Identifiers

PMID32878764
PMCPMC7470506

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.