ArticleCirculation research2020
Gene Therapy With the DWORF Micropeptide Attenuates Cardiomyopathy in Mice.
Open access · bronzeAbstract readLetter
In one paragraph
Article in Circulation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 43 citations in OpenAlex.
- RNA splicing and cardiovascular disease: a guide for cardiologists.European heart journal · 2026Review
- The identity crisis of cryptic lncRNAs: when non-coding RNAs translate into small peptides.The EMBO journal · 2026Review
- Microprotein, macro-effect: DWORF as a therapeutic strategy in heart failure.Frontiers in cell and developmental biology · 2026Review
- Mitochondrial remodeling in heart failure with reduced ejection fraction.Frontiers in physiology · 2026Review
- Microproteins in Metabolic Biology: Emerging Functions and Potential Roles as Nutrient-Linked Biomarkers.International journal of molecular sciences · 2025Review
- RNA Therapeutics in Heart Failure.Journal of cardiovascular translational research · 2025Review
- RRAD-reduction reveals efficacy of targeting L-type calcium channel regulation for treatment of heart failure.Cardiovascular research · 2025Article
- Allosteric Modulation of SERCA Pumps in Health and Disease: Structural Dynamics, Posttranslational Modifications, and Therapeutic Potential.Journal of molecular biology · 2025Review
- DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function.Circulation research · 2025Article
- Structural Elements of Dwarf Open Reading Frame Required for Activation of the Sarco-Endoplasmic Reticulum Calcium Pump.Biochemistry · 2025Article
- Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart.Journal of molecular and cellular cardiology plus · 2025Article
- Abnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout mice.Science advances · 2025Article
- Microproteins in Metabolism.Cells · 2025Review
- Emerging roles for microproteins as critical regulators of endoplasmic reticulum function and cellular homeostasis.Seminars in cell & developmental biology · 2025Review
- Eukaryotic Microproteins.Annual review of biochemistry · 2025Review
- DWORF expression is reduced in a large animal model of Duchenne muscular dystrophy.Disease models & mechanisms · 2025Article
- AEOL-induced NRF2 activation and DWORF overexpression mitigate myocardial I/R injury.Molecular medicine (Cambridge, Mass.) · 2025Article
- Pumping the Breaks on Acantholytic Skin Disorders: Targeting Calcium Pumps, Desmosomes, and Downstream Signaling in Darier, Hailey-Hailey, and Grover Disease.The Journal of investigative dermatology · 2025Review
- Microprotein-encoding RNA regulation in cells treated with pro-inflammatory and pro-fibrotic stimuli.BMC genomics · 2024Article
- Pathological mutations in the phospholamban cytoplasmic region affect its topology and dynamics modulating the extent of SERCA inhibition.Biochimica et biophysica acta. Biomembranes · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Catherine A MakarewichDivision of Molecular Cardiovascular Biology of the Heart Institute, Cincinnati Children's Hospital Medical Center (C.A.M., A.M.G.).
Svetlana BezprozvannayaDivision of Molecular Cardiovascular Biology of the Heart Institute, Cincinnati Children's Hospital Medical Center (C.A.M., A.M.G.).
Aaron M GibsonDivision of Molecular Cardiovascular Biology of the Heart Institute, Cincinnati Children's Hospital Medical Center (C.A.M., A.M.G.).
Rhonda Bassel-DubyMolecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center (S.B., R.B.-D., E.N.O.).
Eric N OlsonMolecular Biology and Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center (S.B., R.B.-D., E.N.O.).
Cincinnati Children's Hospital Medical Center · USSouthwestern Medical Center · USThe University of Texas Southwestern Medical Center · US
Funding
Training CoreP50HD087351 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI MAMMEN, PRADEEP P.A. · 2020 to 2024
$8.0MTraining CoreU54HD087351 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI OLSON, ERIC N · 2015 to 2019
$7.8MDeciphering the role of a novel micropeptide in cardiac function and dysfunctionR01HL130253 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA, OLSON, ERIC N · 2016 to 2023
$4.4MMolecular Dissection of Myoblast Fusion In Muscle Development and RegenerationR01AR067294 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA, OLSON, ERIC N · 2015 to 2019
$1.8MChemically assisted remodeling of infarcted heart tissue by targeting Wnt lipidationR01HL138426 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI BASSEL-DUBY, RHONDA · 2017 to 2020
$1.7MDissecting the role of novel calcium regulatory proteins in the cardiovascular systemR00HL141630 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI MAKAREWICH, CATHERINE A · 2020 to 2022
$747kRodent Ultrasound Imaging SystemS10RR023729 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2009 to 2009
$290kDissecting the role of novel calcium regulatory proteins in the cardiovascular systemK99HL141630 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI MAKAREWICH, CATHERINE A · 2018 to 2019
$177kNCRR NIH HHS S10 RR023729NHLBI NIH HHS K99 HL141630NHLBI NIH HHS R00 HL141630NHLBI NIH HHS R01 HL130253NHLBI NIH HHS R01 HL138426NIAMS NIH HHS R01 AR067294NICHD NIH HHS P50 HD087351NICHD NIH HHS U54 HD087351
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsCardiomyopathiesDependovirusFemaleGenetic TherapyGenetic VectorsMaleMicePeptidesPromoter Regions, GeneticSarcoplasmic Reticulum Calcium-Transporting ATPasesTroponin TDWORF peptide, mousePeptidesSarcoplasmic Reticulum Calcium-Transporting ATPasesTroponin Tcalciumcardiomyopathygene deletionheart failuremice
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.