Evidence map›Paper›PMID 32878478›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2020

Lifestyle Moderates Genetic Risk of Venous Thromboembolism: The ARIC Study.

Christina R Evans, Ching-Ping Hong, Aaron R Folsom, Susan R Heckbert, Nicholas L Smith, Kerri Wiggins, Pamela L Lutsey, Mary Cushman

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Article
  6. Multi-ancestry polygenic risk scores for venous thromboembolism.medRxiv : the preprint server for health sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christina R EvansDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (C.R.E.).
Ching-Ping HongDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (C.-P.H., A.R.F., P.L.L.).
Aaron R FolsomDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (C.-P.H., A.R.F., P.L.L.).
Susan R HeckbertCardiovascular Health Research Unit, Department of Epidemiology (S.R.H., N.L.S.), University of Washington, Seattle.
Nicholas L SmithCardiovascular Health Research Unit, Department of Epidemiology (S.R.H., N.L.S.), University of Washington, Seattle.
Kerri WigginsCardiovascular Health Research Unit, Department of Medicine (K.W.), University of Washington, Seattle.
Pamela L LutseyDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (C.-P.H., A.R.F., P.L.L.).
Mary CushmanDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington (M.C.).

Funding

Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
NHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS R01 HL059367
6 · The paper itself

Abstract

objectiveVenous thromboembolism (VTE) is a common disease that has a genetic basis. Lifestyle factors contribute to risk, but it is unknown whether healthy lifestyle can mitigate the genetic risk. We studied whether greater adherence to the American Heart Association's cardiovascular health metric, Life's Simple 7 (LS7), is associated with lower incidence of VTE in individuals across categories of a genetic risk score (GRS) for VTE. Approach AND

resultsWe followed 9026 White participants from the ARIC (Atherosclerosis Risk in Communities) Study, a prospective cohort enrolled in 1987 to 1989 until 2015. We tested the joint associations with VTE of a validated VTE GRS comprising 5 well-known gene variants and baseline LS7 categories. There were 466 incident VTE events over 22.8 years. Participants with an optimal LS7 score had a lower incidence of VTE (3.9%) than those with inadequate LS7 (5.7%). Compared with the high GRS and inadequate LS7 group (hazard ratio=1), those with high GRS and optimal LS7 indeed had a reduced hazard ratio of VTE: 0.65 (95% CI, 0.48-0.89). The group with low GRS and optimal LS7 had the lowest hazard ratio of VTE (0.39 [95% CI, 0.25-0.61]). Of the LS7 components, in all GRS groups, the factor most strongly protective for VTE was normal weight.

conclusionsAmong people at low or high genetic risk for VTE, healthier lifestyle factors, particularly normal weight, were associated with a lower incidence of VTE. Further studies should determine the impact of lifestyle changes among patients at high genetic risk of VTE, such as in thrombophilic families.

Indexed as

Gene-Environment InteractionHealthy LifestyleRisk Reduction BehaviorDiet, HealthyExerciseFemaleGenetic Predisposition to DiseaseHealth StatusHumansIncidenceMaleMiddle AgedPhenotypeProspective StudiesProtective FactorsRisk Assessmentgeneticshealth statuslifestylerisk factorvenous thromboembolism

Identifiers

PMID32878478
PMCPMC8498945

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.