ArticleAntibiotics (Basel, Switzerland)2020
Levers to Improve Antibiotic Treatment of Lambs via Drinking Water in Sheep Fattening Houses: The Example of the Sulfadimethoxine/Trimethoprim Combination.
Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Predicted PK/PD inadequacy of amoxicillin delivered in drinking water against respiratory pathogens in post-weaning piglets: can time-restricted dosing improve animals' exposure and potential treatment efficacy?Veterinary and animal science · 2026Article
- Population pharmacokinetic modeling of sulfadimethoxine, sulfadiazine and sulfamethoxazole combined to trimethoprim in pigs.The veterinary quarterly · 2025Article
- Delivery strategies to improve piglets exposure to oral antimicrobials.BMC veterinary research · 2024Article
- Optimization of Veterinary Antimicrobial Treatment in Companion and Food Animals.Antibiotics (Basel, Switzerland) · 2022Article
- Dose-dependent impact of enrofloxacin on broiler chicken gut resistome is mitigated by synbiotic application.Frontiers in microbiology · 2022Article
- Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 11:EFSA journal. European Food Safety Authority · 2021Article
- Enrofloxacin Dose Optimization for the Treatment of Colibacillosis in Broiler Chickens Using a Drinking Behaviour Pharmacokinetic Model.Antibiotics (Basel, Switzerland) · 2021Article
- Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
To limit the spread of bacterial diseases in sheep fattening houses, antibiotics are often administered collectively. Collective treatments can be delivered by drinking water but data on the drug's solubility in water or on plasma exposure of the animals are lacking. We first assessed the solubility of products containing sulfadimethoxine (SDM), associated or not with trimethoprim (TMP), in different waters. We then compared in lambs the SDM and TMP pharmacokinetic profiles after individual intravenous (IV) and oral administrations of SDM-TMP in experimental settings (n = 8) and after a collective treatment by drinking water with SDM-TMP or SDM alone in a sheep fattening house (n = 100 for each treatment). The individual water consumption during the collective treatments was also monitored to characterize the ingestion variability. We showed that TMP had a short terminal half-life and very low oral bioavailability, demonstrating that it would be unable to potentiate SDM by oral route. Conversely, SDM had a long terminal half-life of 18 h and excellent oral bioavailability. However, delivery by drinking water resulted in a very high interindividual variability of SDM plasma concentrations, meaning that although disease spread could be controlled at the group level, some individuals would inevitably be under- or over-exposed to the antibiotic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.