Evidence map›Paper›PMID 32878082›Full record

ArticlePolymers2020

Synthesis of MOF525/PEDOT Composites as Microelectrodes for Electrochemical Sensing of Dopamine.

Season S Chen, Po-Chun Han, Wai-Kei Kuok, Jian-Yu Lu, Yesong Gu, Tansir Ahamad, Saad M Alshehri, Hailemichael Ayalew, Hsiao-Hua Yu, Kevin C-W Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Season S ChenDepartment of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
Po-Chun HanProgram of Green Materials and Precision Devices, National Taiwan University, Taipei 10617, Taiwan.
Wai-Kei KuokDepartment of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
Jian-Yu LuDepartment of Chemical and Materials Engineering, Tunghai University, No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung City 407224, Taiwan.
Yesong GuDepartment of Chemical and Materials Engineering, Tunghai University, No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung City 407224, Taiwan.
Tansir AhamadDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Saad M AlshehriDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Hailemichael AyalewSmart Organic Materials Laboratory, Institute of Chemistry, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0002-7622-8277
Hsiao-Hua YuSmart Organic Materials Laboratory, Institute of Chemistry, Academia Sinica, Taipei 11529, Taiwan.ORCID 0000-0002-3603-6932
Kevin C-W WuDepartment of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan.
National Taiwan University · TWInstitute of Chemistry, Academia Sinica · TWKing Saud University · SATunghai University · TW

Funding

Ministry of Science and Technology, Taiwan 108-2638-E-002-003-MY2
6 · The paper itself

Abstract

Dopamine (DA) is an important neurotransmitter responsible for the functions and activities of multiple systems in human. Electrochemical detection of DA has the advantages of fast analysis and cost-effectiveness, while a regular electrode probe is restricted to laboratory use because the probe size is too large to be suitable for an in vivo or in vitro analysis. In this study, we have developed porphyrin-based metal organic framework (MOF525) and poly(3,4-ethylenedioxythiophene) (PEDOT)-based composites to modify microelectrode for DA detection. Two types of PEDOT monomers with different functional groups were investigated in this study. By varying the monomer ratios, electrolyte concentrations, and electropolymerization temperature, it was found that the PEDOT monomer containing carboxylic group facilitated the formation of regular morphology during the electropolymerization process. The uniform morphology of the PEDOT promoted the electron transmission efficiency in the same direction, while the MOF525 provided a large reactive surface area for electrocatalysis of DA. Thus, the MOF525/PEDOT composite improved the sensitivity-to-noise ratio of DA signaling, where the sensitivity reached 11 nA/μM in a good linear range of 4-100 µM. In addition, porphyrin-based MOF could also increase the selectivity to DA against other common clinical interferences, such as ascorbic acid and uric acid. The as-synthesized microelectrode modified with MOF525/PEDOT in this study exhibited great potential in real time analysis.

Indexed as

biosensordopamine detectionelectrocatalysiselectropolymerizationmicroelectrodepoly(3,4-ethylenedioxythiophene) (PEDOT)

Identifiers

PMID32878082
PMCPMC7564993
OpenAlexW3082562108

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.