ArticlePolymers2020
pH-Sensitive Starch-Based Hydrogels: Synthesis and Effect of Molecular Components on Drug Release Behavior.
Article in Polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 66 citations in OpenAlex.
- Thermogelling Hydrogel for Sustained Topical Delivery of Quercetin for the Treatment of Atopic Dermatitis.AAPS PharmSciTech · 2026Article
- Natural Polymer-Based Hydrogels for Localized Therapy in Inflammatory Bowel Disease: From Smart Materials to Clinical Translation.Journal of inflammation research · 2026Review
- Stimuli-Responsive Starch-Based Biopolymer Coatings for Smart and Sustainable Fertilizers.Gels (Basel, Switzerland) · 2025Review
- pH-responsive release of small molecule pharmaceuticals from a reworked adsorbent hydrogel for environmental applications.RSC advances · 2025Article
- A Comprehensive Review on Starch-Based Hydrogels: From Tradition to Innovation, Opportunities, and Drawbacks.Polymers · 2024Review
- A hybrid structure based on silk fibroin/PVA nanofibers and alginate/gum tragacanth hydrogel embedded with cardamom extract.Scientific reports · 2024Article
- Starch-Based Hydrogels as a Drug Delivery System in Biomedical Applications.Gels (Basel, Switzerland) · 2023Review
- Exploring the Drug-Loading and Release Ability of FucoPol Hydrogel Membranes.International journal of molecular sciences · 2023Article
- Synthesis and Evaluation of Alginate-Based Nanogels as Sustained Drug Carriers for Caffeine.ACS omega · 2023Article
- Synthesis and Characterization of Novel Magnetic Nano-Biocomposite Hydrogels Based on Starch-ACS omega · 2023Article
- Controlled Drug Release from Nanoengineered Polysaccharides.Pharmaceutics · 2023Review
- Essential Oils Distilled from Colombian Aromatic Plants and Their Constituents as Penetration Enhancers for Transdermal Drug Delivery.Molecules (Basel, Switzerland) · 2023Article
- Development of Tofacitinib Loaded pH-Responsive Chitosan/Mucin Based Hydrogel Microparticles: In-Vitro Characterization and Toxicological Screening.Gels (Basel, Switzerland) · 2023Article
- A Double-Layer Hydrogel Dressing with High Mechanical Strength and Water Resistance Used for Drug Delivery.Molecules (Basel, Switzerland) · 2023Article
- Article
- Development of Polymeric-Based Formulation as Potential Smart Colonic Drug Delivery System.Polymers · 2022Article
- Synthesis and Characterization of Novel Patchouli Essential Oil Loaded Starch-Based Hydrogel.Gels (Basel, Switzerland) · 2022Article
- Plant Polysaccharides in Engineered Pharmaceutical Gels.Bioengineering (Basel, Switzerland) · 2022Review
- Development of hydrogel based on Carboxymethyl cellulose/poly(4-vinylpyridine) for controlled releasing of fertilizers.BMC chemistry · 2022Article
- Current Trends in Biomedical Hydrogels: From Traditional Crosslinking to Plasma-Assisted Synthesis.Polymers · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The drug release behavior of pH-sensitive starch-based hydrogels was systematically studied. Hydrogels were synthesized by copolymerization of acrylic acid (AA) and other acrylate comonomers onto the starch backbone. The hydrophilic agents 2-hydroxy ethyl methacrylate (HEMA), and acrylamide (AAm), as well as the hydrophobic butyl-methacrylate (BMA), were utilized as comonomers. Methylene-bisacrylamide (MBA) was employed as a crosslinking agent. The synthesized hydrogels were loaded with caffeine as a model drug. The effects of the hydrophobic/hydrophilic character of the comonomers and chemical crosslinking on the swelling capacity and the release rate of caffeine were investigated. The use of the crosslinking agent and hydrophobic monomers decreased the swelling capacity of the hydrogels. The release rate of caffeine increased with the presence of a hydrophobic monomer. The fastest release was obtained with the AA/BMA/AAm formulation, and the slowest release was observed with the AA/HEMA/AAm formulation. The transport mechanism was controlled by Fickian diffusion in formulations containing AAm, and controlled by the polymer-relaxation mechanism in formulations containing MBA. Overall, our results showed that the swelling and drug delivery behavior can be tuned by varying the chemical composition of the copolymer formulations. These starch-based hydrogels can be useful as drug delivery devices in many biomedical applications.
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