ReviewJournal of musculoskeletal & neuronal interactions2020
Obesity, osteoporosis and bone metabolism.
Review in Journal of musculoskeletal & neuronal interactions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 197 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Investigation of Changes in Body Composition and Bone Turnover Markers in People With Obesity After Treatment With Tirzepatide Versus Liraglutide. A Prospective Cohort Study.
The Effectiveness of Whole Body Vibration Training in Improving Brain Activity, Bone Mineral Density, Quality of Life, and Biomarkers for the Older People With Dynapenic Abdominal Obesity
Who cites it
197 citing papers in PubMed, 1 synthesis or guideline pooled it, 245 citations in OpenAlex.
- Associated factors of osteoporosis in Chinese patients with rheumatoid arthritis: A systematic review and meta-analysis.Journal of the Chinese Medical Association : JCMA · 2024Pooled it
- The influence of physical activity intensity on bone mineral density and trabecular bone score in young adults with overweight and obesity.International journal of obesity (2005) · 2025Trial
- Trial
- Triphenyl phosphate promotes lipid accumulation in human mesenchymal stem cells through metabolic stress pathways.Archives of toxicology · 2026Article
- Effects of high-fat diet and treadmill running on bone marrow fat and bone properties in young male mice.Physiological reports · 2026Article
- Sleep-Disordered Breathing and Decreased Bone Mineral Density: Masking Effects of Body Mass Index.Obesity facts · 2026Article
- The role and therapeutic potential of vitamins in fracture healing.Nutrition journal · 2026Review
- The saturation effect of body mass index on femoral neck bone mineral density in a sample of apparently healthy older Syrians: A cross-sectional study.The Journal of international medical research · 2026Article
- Anthropometric, Functional, and Haemodynamic Changes in Bariatric Surgery Patients Within the Polish KOS-BAR Pathway: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Multi-scale modelling of mouse tibia loading reveals the critical role of muscle insertion surfaces.Biomechanics and modeling in mechanobiology · 2026Article
- Geranylgeraniol promotes osteoblast differentiation and inhibits osteoclastogenesis through MAPK and nuclear receptor signaling.The Journal of biological chemistry · 2026Article
- 2025 Obesity Fact Sheet for Korea: Prevalence of Obesity, Abdominal Obesity from 2014 to 2023 and Prevalence of Chronic Disease by Obesity Status.Journal of obesity & metabolic syndrome · 2026Article
- Does body mass index independently affect functional outcomes after conservatively treated distal radius fractures? a retrospective cohort study.BMC musculoskeletal disorders · 2026Article
- Article
- Independent and synergistic associations of cumulative body roundness index and its variability with fragility fracture risk.Lipids in health and disease · 2026Article
- Geriatric Nutritional Risk Index as a Predictor for Osteoporosis Risk in Elderly Patients with Type 2 Diabetes Mellitus: A Hospital-Based Study.Diagnostics (Basel, Switzerland) · 2026Article
- Abdominal fat volume predicts bone mass reduction in women with metabolic syndrome: an energy spectral CT analysis.BMC medical imaging · 2026Article
- The Role of Glucose-Dependent Insulinotropic Polypeptide (GIP) in Bone Metabolism.International journal of molecular sciences · 2026Review
- Impact of metabolic score for visceral fat on bone health in adolescent population: a cross-sectional study perspective.Frontiers in nutrition · 2026Article
- Dietary patterns and osteoporosis risk in a high-altitude population: the roles of gut microbiota and plasma metabolites in a case-control study.Frontiers in nutrition · 2026Article
137 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity and osteoporosis have become major global health problems over the last decades as their prevalence is increasing. The interaction between obesity and bone metabolism is complex and not fully understood. Historically, obesity was thought to be protective against osteoporosis;however, several studies have challenged this belief. Even though the majority of the studies suggest that obesity has a favourable effect on bone density, it is unclear what the effect of obesity is on skeletal microarchitecture. Additionally, the effects of obesity on skeletal strength might be site-dependent as obese individuals are at higher risk of certain fractures. Several mechanical, biochemical and hormonal mechanisms have been proposed to explain the association between the adipose tissue and bone. Mechanical loading has positive effects on bone health, but this may not suffice in obesity. Low-grade systemic inflammation is probably harmful to the bone and increased bone marrow adipogenesis may lead to decreased bone mass in obese individuals. Finally, visceral abdominal fat may exert different actions to the bone compared with the subcutaneous fat. Achieving a better understanding of the association between adipose and bone tissue may help to identify new molecular therapeutic targets that will promote osteoblastic activity and/or inhibit adipogenesis and osteoclastic activity.
Indexed as
Identifiers
32877973PMC7493444W3083607101What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.