Evidence map›Paper›PMID 32877970›Full record

ArticleJournal of musculoskeletal & neuronal interactions2020

Exploring the brain-body composition relationship in Huntington's disease.

Mitchell Turner, Alvaro Reyes, Danielle M Bartlett, Scott Culpin, Nicolas H Hart, Luca Hardt, Kirk Feindel, Govinda R Poudel, Mel Ziman, Travis M Cruickshank

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of musculoskeletal & neuronal interactions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Rehabilitation outcomes in Huntington disease patients with low body mass index.Journal of musculoskeletal & neuronal interactions · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Mitchell TurnerSchool of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Alvaro ReyesFacultad de Ciencias de la Rehabilitacion. Universidad Andrés Bello, Chile.
Danielle M BartlettSchool of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Scott CulpinSchool of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Nicolas H HartSchool of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Luca HardtInstitute for Cardiovascular Research and Sports Medicine, German Sport University, Cologne, Germany.
Kirk FeindelCentre for Microscopy, Characterisation and Analysis, University of Western Australia, Australia.
Govinda R PoudelMary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
Mel ZimanSchool of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Travis M CruickshankSchool of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
Edith Cowan University · AUAustralian Catholic University · AUGerman Sport University Cologne · DEPerron Institute for Neurological and Translational Science · AUThe University of Notre Dame Australia · AUUniversidad Andrés Bello · CLUniversity of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveChanges in body composition are a common feature of Huntington's disease (HD) and are associated with disease progression. However, whether these changes in body composition are associated with degeneration of the striatum is unknown. This study aimed to explore the associations between body composition metrics and striatal brain volume in individuals with premanifest HD and healthy controls.

methodsTwenty-one individuals with premanifest HD and 22 healthy controls participated in this cross-sectional study. Body composition metrics were measured via dual-energy X-ray absorptiometry. Structural magnetic resonance imaging of subcortical structures of the brain was performed to evaluate striatal volume.

resultsThere were no significant differences in body composition metrics between the premanifest HD and healthy controls group. Striatal volume was significantly reduced in individuals with premanifest HD compared to healthy controls. A significant association between bone mineral density (BMD) and right putamen volume was also observed in individuals with premanifest HD.

conclusionThese findings show striatal degeneration is evident during the premanifest stages of HD and associated with BMD. Additional longitudinal studies are nevertheless needed to confirm these findings.

Indexed as

Body CompositionAbsorptiometry, PhotonAdultAgedBone DensityBrainCross-Sectional StudiesFemaleHumansHuntington DiseaseMagnetic Resonance ImagingMaleMiddle AgedOrgan SizeBone mineral densityCaudate volumeFat percentagePutamen VolumeStriatum volume

Identifiers

PMID32877970
PMCPMC7493441
OpenAlexW3083735726

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.