ArticleArchives of gerontology and geriatrics
Death risk stratification in elderly patients with covid-19. A comparative cohort study in nursing homes outbreaks.
Article in Archives of gerontology and geriatrics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Respiratory and Pleural Pathogens in Octogenarians Hospitalized with COVID-19: Impact of Secondary Bacterial Pneumonia on Day-5 SOFA and Mortality.Microorganisms · 2026Article
- Living in endemic area for infectious diseases is associated to differences in immunosenescence and inflammatory signatures.Frontiers in immunology · 2025Article
- Safety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study.Signal transduction and targeted therapy · 2024Article
- Sustainability in Internal Medicine: A Year-Long Ward-Wide Observational Study.Journal of personalized medicine · 2024Article
- Survival Impact of an On-Site Medicalization Program in the Control of COVID-19 Outbreaks in 11 Nursing Homes.Journal of clinical medicine · 2023Article
- Nosocomial COVID-19: A Nationwide Spanish Study.Gerontology · 2023Observational
- Are Older People Really More Susceptible to SARS-CoV-2?Aging and disease · 2022Article
- COVID-19 Vaccines in Older Adults: Challenges in Vaccine Development and Policy Making.Clinics in geriatric medicine · 2022Review
- Changes in mortality trends amongst common diseases during the COVID-19 pandemic in Sweden.Scandinavian journal of public health · 2022Article
- Article
- Prognosis of COVID-19 pneumonia can be early predicted combining Age-adjusted Charlson Comorbidity Index, CRB score and baseline oxygen saturation.Scientific reports · 2022Article
- Performance of prediction models for short-term outcome in COVID-19 patients in the emergency department: a retrospective study.Annals of medicine · 2021Article
- Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19.JCI insight · 2021Article
- Risk Factors for COVID-19 Morbidity and Mortality in Institutionalised Elderly People.International journal of environmental research and public health · 2021Article
- Key epidemiological drivers and impact of interventions in the 2020 SARS-CoV-2 epidemic in England.Science translational medicine · 2021Article
- The Italian document: decisions for intensive care when there is an imbalance between care needs and resources during the COVID-19 pandemic.Annals of intensive care · 2021Article
- Safety and Efficacy of Convalescent Plasma in Elderly COVID-19 Patients: The RESCUE Trial.Mayo Clinic proceedings. Innovations, quality & outcomes · 2021Article
- Epidemiology and clinical features of COVID-19 outbreaks in aged care facilities: A systematic review and meta-analysis.EClinicalMedicine · 2021Article
- Clinical Characteristics, Frailty, and Mortality of Residents With COVID-19 in Nursing Homes of a Region of Madrid.Journal of the American Medical Directors Association · 2021Article
- Was R < 1 before the English lockdowns? On modelling mechanistic detail, causality and inference about Covid-19.PloS one · 2021Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elderly people are more severely affected by COVID-19. Nevertheless scarce information about specific prognostic scores for this population is available. The main objective was to compare the accuracy of recently developed COVID-19 prognostic scores to that of CURB-65, Charlson and PROFUND indices in a cohort of 272 elderly patients from four nursing homes, affected by COVID-19. Accuracy was measured by calibration (calibration curves and Hosmer-Lemeshov (H-L) test), and discriminative power (area under the receiver operation curve (AUC-ROC). Negative and positive predictive values (NPV and PPV) were also obtained. Overall mortality rate was 22.4 %. Only ACP and Shi et al. out of 10 specific COVID-19 indices could be assessed. All indices but CURB-65 showed a good calibration by H-L test, whilst PROFUND, ACP and CURB-65 showed best results in calibration curves. Only CURB-65 (AUC-ROC = 0.81 [0.75-0.87])) and PROFUND (AUC-ROC = 0.67 [0.6-0.75])) showed good discrimination power. The highest NPV was obtained by CURB-65 (95 % [90-98%]), PROFUND (93 % [77-98%]), and their combination (100 % [82-100%]); whereas CURB-65 (74 % [51-88%]), and its combination with PROFUND (80 % [50-94%]) showed highest PPV. PROFUND and CURB-65 indices showed the highest accuracy in predicting death-risk of elderly patients affected by COVID-19, whereas Charlson and recent developed COVID-19 specific tools lacked it, or were not available to assess. A comprehensive clinical stratification on two-level basis (basal death risk due to chronic conditions by PROFUND index, plus current death risk due to COVID-19 by CURB-65), could be an appropriate approach.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.