Evidence map›Paper›PMID 32877707›Full record

ArticleEnvironmental research2020

Assessment of multiclass pharmaceutical active compounds (PhACs) in hospital WWTP influent and effluent samples by UHPLC-Orbitrap MS: Temporal variation, removals and environmental risk assessment.

Christina I Kosma, Margarita G Kapsi, Panagiotis-Spyridon G Konstas, Epameinondas P Trantopoulos, Vasiliki I Boti, Ioannis K Konstantinou, Triantafyllos A Albanis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

  1. Literature Review: Evaluation of Drug Removal Techniques in Municipal and Hospital Wastewater.International journal of environmental research and public health · 2022
    Pooled it
  2. Review
  3. Article
  4. Tracing antibiotics in sewers: Concentrations, measurement techniques, and mathematical approaches.Water science and technology : a journal of the International Association on Water Pollution Research · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christina I KosmaDepartment of Chemistry, University of Ioannina, Ioannina, 45110, Greece.
Margarita G KapsiDepartment of Chemistry, University of Ioannina, Ioannina, 45110, Greece.
Panagiotis-Spyridon G KonstasDepartment of Chemistry, University of Ioannina, Ioannina, 45110, Greece.
Epameinondas P TrantopoulosDepartment of Chemistry, University of Ioannina, Ioannina, 45110, Greece.
Vasiliki I BotiDepartment of Chemistry, University of Ioannina, Ioannina, 45110, Greece.
Ioannis K KonstantinouDepartment of Chemistry, University of Ioannina, Ioannina, 45110, Greece; University Research Center of Ioannina (URCI), Institute of Environment and Sustainable Development, Ioannina, 45110, Greece. Electronic address: iokonst@uoi.gr.
Triantafyllos A AlbanisDepartment of Chemistry, University of Ioannina, Ioannina, 45110, Greece; University Research Center of Ioannina (URCI), Institute of Environment and Sustainable Development, Ioannina, 45110, Greece. Electronic address: talbanis@uoi.gr.
University of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nowadays the occurrence and associated risks of Pharmaceutical Active Compounds (PhACs) in the aquatic environment comprises a major issue. In the present study, a comprehensive survey on contamination profiles, occurrence, removals, temporal variation and ecological risk of multiclass multiresidue PhACs, such as antibiotics, non-steroidal anti-inflammatories, lipid regulators and phsychiatrics, (including past and newly monitored PhACs as well as some of their metabolites) was performed in wastewaters from the WWTP of Ioannina University hospital along one year period on a monthly sampling basis. WWTP influent and effluent samples were analyzed for physicochemical quality parameters and PhACs concentration levels using Ultra High Performance Liquid Chromatography-Orbitrap-Mass Spectrometry (UHPLC-Orbitrap-MS), after Solid Phase Extraction (SPE) through Oasis HLB cartridges. Influent concentrations ranged between < LOQ (Limit of Quantification) for diclofenac and tolfenamic acid and 48586 ng/L for caffeine, while effluent concentrations between < LOQ for tolfenamic acid and simvastatin and 3361 ng/L for caffeine. Removal efficiencies ranged between -132.6% for venlafaxine and 100% for caffeine. Environmental risk assessment by means of Risk Quotient (RQ) for maximum and minimum concentration levels as well as optimized by the frequency of exceeding toxicity threshold values, RQ

Indexed as

Pharmaceutical PreparationsWater Pollutants, ChemicalChromatography, High Pressure LiquidEnvironmental MonitoringHospitalsHumansRisk AssessmentWaste Disposal, FluidWastewaterPharmaceutical PreparationsWastewaterWater Pollutants, ChemicalEliminationHospital wastewatersMetabolitesOccurrencePharmaceuticalsRisk characterization

Identifiers

PMID32877707
PMCPMC7456450
OpenAlexW3082023091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.