Evidence map›Paper›PMID 32877647›Full record

ArticleStructure (London, England : 1993)2020

RSV M2-1 Protein in Complex with RNA: Old Questions Are Answered and a New One Emerges.

Victoria Anne Kleiner, Rachel Fearns

Abstract readComment
PubMed Publisher
In one paragraph

Article in Structure (London, England : 1993), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Victoria Anne KleinerDepartment of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.
Rachel FearnsDepartment of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: rfearns@bu.edu.

Funding

Mechanisms of Marburg virus gene expressionR01AI133486 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FEARNS, RACHEL, MUHLBERGER, ELKE C · 2018 to 2022
$2.7M
The B cell repertoire as a window into the nature and impact of the lung viromeR33HL137081 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FEARNS, RACHEL, KEPLER, THOMAS B · 2019 to 2021
$2.4M
Initiation and regulation of RSV mRNA transcription and genome replicationR01AI113321 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FEARNS, RACHEL · 2014 to 2017
$1.7M
Interplay between respiratory syncytial virus and nucleotide biosynthesis pathwaysR21AI147659 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DUTCH, REBECCA E., FEARNS, RACHEL · 2020 to 2021
$455k
NHLBI NIH HHS R33 HL137081NIAID NIH HHS R01 AI113321NIAID NIH HHS R01 AI133486NIAID NIH HHS R21 AI147659
6 · The paper itself

Abstract

The respiratory syncytial virus (RSV) M2-1 protein is essential for virus transcription. In this issue of Structure, Gao et al. (2020) describe the crystal structure of M2-1 in complex with RNA. This structure provides new insight into the RSV transcription mechanism but also raises an intriguing question regarding M2-1's function.

Indexed as

Respiratory Syncytial Virus, HumanHumansRNAViral ProteinsVirus ReplicationRNAViral Proteinshuman metapneumovirusM2-1 proteinnon-segmented negative strand RNA virusrespiratory syncytial virusRNA-dependent RNA polymerasetranscription

Identifiers

PMID32877647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.